Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate
Simultaneous thermogravimetry and differential scanning calorimetry (TG–DSC), differential scanning calorimetry (DSC) and coupled thermogravimetry coupled to infrared spectroscopy (TG-FTIR) were used to study the antihypertensive drug amlodipine besylate. The TG–DSC curves provided information conce...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2015-04, Vol.120 (1), p.889-892 |
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| container_title | Journal of thermal analysis and calorimetry |
| container_volume | 120 |
| creator | Silva, A. C. M. Gálico, D. A. Guerra, R. B. Perpétuo, G. L. Legendre, A. O. Rinaldo, D. Bannach, G. |
| description | Simultaneous thermogravimetry and differential scanning calorimetry (TG–DSC), differential scanning calorimetry (DSC) and coupled thermogravimetry coupled to infrared spectroscopy (TG-FTIR) were used to study the antihypertensive drug amlodipine besylate. The TG–DSC curves provided information concerning the thermal stability and the decomposition steps of the compound, while the DSC technique allowed us to confirm that the melting occurs concomitantly with the decomposition of the sample. By using the TG coupled to FTIR coupled techniques, it was possible to identify ammonia and methanol and CO
2
as compounds released during the thermal degradation of the drug. |
| doi_str_mv | 10.1007/s10973-014-3992-z |
| format | Article |
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2
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2
as compounds released during the thermal degradation of the drug.</description><subject>Amlodipine</subject><subject>Analytical Chemistry</subject><subject>Carbon dioxide</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Decomposition</subject><subject>Differential scanning calorimetry</subject><subject>Drugs</subject><subject>Hypertension</subject><subject>Inorganic Chemistry</subject><subject>Joining</subject><subject>Measurement Science and Instrumentation</subject><subject>Methyl alcohol</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Thermal stability</subject><subject>Thermogravimetry</subject><issn>1388-6150</issn><issn>1588-2926</issn><issn>1572-8943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kUtr3TAQRk1poWmSH9CdoZt24XTkh2wtQ-gjECg06S4gRvLoRsGWXEkOvfn11cXZXChFCw0z5wg0X1G8Z3DBAPrPkYHomwpYWzVC1NXzq-KEdcNQ1aLmr3Pd5JqzDt4W72J8BAAhgJ0U93cPFGacyphQ2cmmfYluLNNLdyTt58VHm6x3pTeHQQaSfdgvFBK5aJ-oHMO6K3Ge_GgX66hUFPcTJjor3hicIp2_3KfFr69f7q6-Vzc_vl1fXd5Uuu26VHFQeqReYK85G1TXQk0AmqumY9iaRqteGQSk_AfVmFZhjyA4Jxg1B0PNafFxe3cJ_vdKMcnZRk3ThI78GiXjQzcAG2qW0Q8busOJpHXGp4D6gMvLtm571gk2ZOriH1Q-I81We0fG5v6R8OlIyEyiP2mHa4zy-vbnMcs2VgcfYyAjl2BnDHvJQB7ClFuYMocpD2HK5-zUmxMz63YU5KNfg8tL_Y_0F-EBosc</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Silva, A. 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M.</creatorcontrib><creatorcontrib>Gálico, D. A.</creatorcontrib><creatorcontrib>Guerra, R. B.</creatorcontrib><creatorcontrib>Perpétuo, G. L.</creatorcontrib><creatorcontrib>Legendre, A. O.</creatorcontrib><creatorcontrib>Rinaldo, D.</creatorcontrib><creatorcontrib>Bannach, G.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, A. C. M.</au><au>Gálico, D. A.</au><au>Guerra, R. B.</au><au>Perpétuo, G. L.</au><au>Legendre, A. 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The TG–DSC curves provided information concerning the thermal stability and the decomposition steps of the compound, while the DSC technique allowed us to confirm that the melting occurs concomitantly with the decomposition of the sample. By using the TG coupled to FTIR coupled techniques, it was possible to identify ammonia and methanol and CO
2
as compounds released during the thermal degradation of the drug.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-014-3992-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Amlodipine Analytical Chemistry Carbon dioxide Chemistry Chemistry and Materials Science Decomposition Differential scanning calorimetry Drugs Hypertension Inorganic Chemistry Joining Measurement Science and Instrumentation Methyl alcohol Physical Chemistry Polymer Sciences Thermal stability Thermogravimetry |
| title | Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate |
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