Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo

A peptide‐conjugated poly(β‐amino ester) that self‐assembles into micelle‐like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin‐1 (P‐Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach...

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Veröffentlicht in:	Advanced materials (Weinheim) 2015-04, Vol.27 (16), p.2627-2634
Hauptverfasser:	Wang, Yi, Lin, Yao-Xin, Qiao, Zeng-Ying, An, Hong-Wei, Qiao, Sheng-Lin, Wang, Lei, Rajapaksha, R P Yeshan J, Wang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemistry Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Apoptosis Regulatory Proteins - administration & dosage Apoptosis Regulatory Proteins - chemistry Autophagy - physiology Beclin-1 Breast breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Cancer Cell Line, Tumor Drug Delivery Systems Esters Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Interference Lysosomes - drug effects Lysosomes - metabolism Membrane Proteins - administration & dosage Membrane Proteins - chemistry Mice, Nude Micelles Modular Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasm Transplantation Polyethylene Glycols - chemistry polymer Polymers - chemistry Protein Stability Protein Structure, Secondary self-assembly Suppressors therapeutic peptide Tumors
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