Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo
A peptide‐conjugated poly(β‐amino ester) that self‐assembles into micelle‐like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin‐1 (P‐Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2015-04, Vol.27 (16), p.2627-2634 |
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| container_title | Advanced materials (Weinheim) |
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| creator | Wang, Yi Lin, Yao-Xin Qiao, Zeng-Ying An, Hong-Wei Qiao, Sheng-Lin Wang, Lei Rajapaksha, R P Yeshan J Wang, Hao |
| description | A peptide‐conjugated poly(β‐amino ester) that self‐assembles into micelle‐like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin‐1 (P‐Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small‐molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non‐specific bio‐distribution and targeting in the tumor tissues. |
| doi_str_mv | 10.1002/adma.201405926 |
| format | Article |
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The polymer–beclin‐1 (P‐Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small‐molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non‐specific bio‐distribution and targeting in the tumor tissues.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201405926</identifier><identifier>PMID: 25786652</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Acrylates - chemistry ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Apoptosis Regulatory Proteins - administration & dosage ; Apoptosis Regulatory Proteins - chemistry ; Autophagy - physiology ; Beclin-1 ; Breast ; breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - physiopathology ; Cancer ; Cell Line, Tumor ; Drug Delivery Systems ; Esters ; Humans ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Interference ; Lysosomes - drug effects ; Lysosomes - metabolism ; Membrane Proteins - administration & dosage ; Membrane Proteins - chemistry ; Mice, Nude ; Micelles ; Modular ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Neoplasm Transplantation ; Polyethylene Glycols - chemistry ; polymer ; Polymers - chemistry ; Protein Stability ; Protein Structure, Secondary ; self-assembly ; Suppressors ; therapeutic peptide ; Tumors</subject><ispartof>Advanced materials (Weinheim), 2015-04, Vol.27 (16), p.2627-2634</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4866-7e3ea711c0d15cadaa56aadd7b000ea2bcf850682e5cd10150adbd03e5b70d7f3</citedby><cites>FETCH-LOGICAL-c4866-7e3ea711c0d15cadaa56aadd7b000ea2bcf850682e5cd10150adbd03e5b70d7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201405926$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201405926$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25786652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Lin, Yao-Xin</creatorcontrib><creatorcontrib>Qiao, Zeng-Ying</creatorcontrib><creatorcontrib>An, Hong-Wei</creatorcontrib><creatorcontrib>Qiao, Sheng-Lin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Rajapaksha, R P Yeshan J</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><title>Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo</title><title>Advanced materials (Weinheim)</title><addtitle>Adv. Mater</addtitle><description>A peptide‐conjugated poly(β‐amino ester) that self‐assembles into micelle‐like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin‐1 (P‐Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small‐molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non‐specific bio‐distribution and targeting in the tumor tissues.</description><subject>Acrylates - chemistry</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Apoptosis Regulatory Proteins - administration & dosage</subject><subject>Apoptosis Regulatory Proteins - chemistry</subject><subject>Autophagy - physiology</subject><subject>Beclin-1</subject><subject>Breast</subject><subject>breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - physiopathology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Drug Delivery Systems</subject><subject>Esters</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Interference</subject><subject>Lysosomes - drug effects</subject><subject>Lysosomes - metabolism</subject><subject>Membrane Proteins - administration & dosage</subject><subject>Membrane Proteins - chemistry</subject><subject>Mice, Nude</subject><subject>Micelles</subject><subject>Modular</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasm Transplantation</subject><subject>Polyethylene Glycols - chemistry</subject><subject>polymer</subject><subject>Polymers - chemistry</subject><subject>Protein Stability</subject><subject>Protein Structure, Secondary</subject><subject>self-assembly</subject><subject>Suppressors</subject><subject>therapeutic peptide</subject><subject>Tumors</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQxa0K1G5LrxxRjly8HSexnRzDlrYr2lIJaBEXM7EnJZCPxU5a9r8nqy0rbnAaPen3np7mMfZSwFwAxCfoWpzHIFKQeaz22EzIWPAUcvmMzSBPJM9Vmh2wwxC-A0CuQO2zg1jqTCkZz9jXD9RUvAiB2rIhFxXj0K--4f2aLzs32rq7j276Zt2Sr210jV2_Qj_UtqEQVb2P3njCMEQL7Cz5aNkN5CvyNKlJ8Nv6oX_BnlfYBDp-ukfs09nbj4sLfvn-fLkoLrlNpypcU0KohbDghLToEKVCdE6XU2vCuLRVJkFlMUnrBAgJ6EoHCclSg9NVcsReb3NXvv85UhhMWwdLTYMd9WMwQmUyA5Go9D9QneYyS8QGnW9R6_sQPFVm5esW_doIMJsBzGYAsxtgMrx6yh7LltwO__PxCci3wGPd0PofcaY4vSr-Dudbbx0G-rXzov9hlE60NHfX50Z-vk1vvrwDc5X8Bk8Rojc</recordid><startdate>20150424</startdate><enddate>20150424</enddate><creator>Wang, Yi</creator><creator>Lin, Yao-Xin</creator><creator>Qiao, Zeng-Ying</creator><creator>An, Hong-Wei</creator><creator>Qiao, Sheng-Lin</creator><creator>Wang, Lei</creator><creator>Rajapaksha, R P Yeshan J</creator><creator>Wang, Hao</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150424</creationdate><title>Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo</title><author>Wang, Yi ; Lin, Yao-Xin ; Qiao, Zeng-Ying ; An, Hong-Wei ; Qiao, Sheng-Lin ; Wang, Lei ; Rajapaksha, R P Yeshan J ; Wang, Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4866-7e3ea711c0d15cadaa56aadd7b000ea2bcf850682e5cd10150adbd03e5b70d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acrylates - chemistry</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Apoptosis Regulatory Proteins - administration & dosage</topic><topic>Apoptosis Regulatory Proteins - chemistry</topic><topic>Autophagy - physiology</topic><topic>Beclin-1</topic><topic>Breast</topic><topic>breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - physiopathology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Drug Delivery Systems</topic><topic>Esters</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Interference</topic><topic>Lysosomes - drug effects</topic><topic>Lysosomes - metabolism</topic><topic>Membrane Proteins - administration & dosage</topic><topic>Membrane Proteins - chemistry</topic><topic>Mice, Nude</topic><topic>Micelles</topic><topic>Modular</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasm Transplantation</topic><topic>Polyethylene Glycols - chemistry</topic><topic>polymer</topic><topic>Polymers - chemistry</topic><topic>Protein Stability</topic><topic>Protein Structure, Secondary</topic><topic>self-assembly</topic><topic>Suppressors</topic><topic>therapeutic peptide</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Lin, Yao-Xin</creatorcontrib><creatorcontrib>Qiao, Zeng-Ying</creatorcontrib><creatorcontrib>An, Hong-Wei</creatorcontrib><creatorcontrib>Qiao, Sheng-Lin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Rajapaksha, R P Yeshan J</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yi</au><au>Lin, Yao-Xin</au><au>Qiao, Zeng-Ying</au><au>An, Hong-Wei</au><au>Qiao, Sheng-Lin</au><au>Wang, Lei</au><au>Rajapaksha, R P Yeshan J</au><au>Wang, Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. 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| subjects | Acrylates - chemistry Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Apoptosis Regulatory Proteins - administration & dosage Apoptosis Regulatory Proteins - chemistry Autophagy - physiology Beclin-1 Breast breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Cancer Cell Line, Tumor Drug Delivery Systems Esters Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Interference Lysosomes - drug effects Lysosomes - metabolism Membrane Proteins - administration & dosage Membrane Proteins - chemistry Mice, Nude Micelles Modular Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasm Transplantation Polyethylene Glycols - chemistry polymer Polymers - chemistry Protein Stability Protein Structure, Secondary self-assembly Suppressors therapeutic peptide Tumors |
| title | Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo |
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