Molecular features of the sortase enzyme family

Bacteria possess complex and varying cell walls with many surface exposed proteins. Sortases are responsible for the covalent attachment of specific proteins to the peptidoglycan of the cell wall of Gram‐positive bacteria. Sortase A of Staphylococcus aureus, which is seen as the archetypal sortase,...

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Veröffentlicht in:	The FEBS journal 2015-06, Vol.282 (11), p.2097-2114
Hauptverfasser:	Bradshaw, William J, Davies, Abigail H, Chambers, Christopher J, Roberts, April K, Shone, Clifford C, Acharya, K. Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases - antagonists & inhibitors Aminoacyltransferases - chemistry Aminoacyltransferases - physiology Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteria - drug effects Bacteria - enzymology Bacterial Infections - drug therapy Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - physiology cell walls crystal structure Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - physiology Enzymes Gram-positive bacteria Humans industrial applications inhibitor design Microbiology Molecular biology molecular mechanism pathogenesis pathogens peptide recognition peptidoglycans Protein Binding Protein Conformation proteins sortase sortase A Species Specificity Staphylococcus aureus Substrate Specificity therapeutics
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