l-Tryptophan Activates Mammalian Target of Rapamycin and Enhances Expression of Tight Junction Proteins in Intestinal Porcine Epithelial Cells

Besides serving as a substrate for protein synthesis, L-tryptophan (L-Trp) is used via serotonin-, kynurenine-, and niacin-synthetic pathways to produce bioactive compounds crucial for whole-body homeostasis. It is unknown whether L-Trp itself can regulate metabolic pathways in animal cells. This st...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of nutrition 2015-06, Vol.145 (6), p.1156-1162
Hauptverfasser:	Wang, Hao, Ji, Yun, Wu, Guoyao, Sun, Kaiji, Sun, Yuli, Li, Wei, Wang, Bin, He, Beibei, Zhang, Qing, Dai, Zhaolai, Wu, Zhenlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Cells, Cultured Claudin-1 - genetics Claudin-1 - metabolism Claudin-4 - genetics Claudin-4 - metabolism Enterocytes - drug effects Enterocytes - metabolism Intestinal Mucosa - metabolism Intestine, Small - drug effects Intestine, Small - metabolism Intestines - cytology Intestines - drug effects Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Occludin - genetics Occludin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Swine Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Tight Junctions - drug effects Tight Junctions - metabolism TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tryptophan - pharmacology Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!