Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

ABSTRACT We investigated the feasibility of the intra‐articular injection of resveratrol for preventing the progression of existing cartilage degeneration in a mouse model of osteoarthritis (OA). The effects of resveratrol on the expression of silent information regulator 2 type 1 (SIRT1), hypoxia‐i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of orthopaedic research 2015-07, Vol.33 (7), p.1061-1070
Hauptverfasser:	Li, Wuyin, Cai, Litao, Zhang, Yun, Cui, Lei, Shen, Gan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Basic Helix-Loop-Helix Transcription Factors - metabolism Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology catabolic factor Collagen Type II - metabolism Drug Evaluation, Preclinical HIF-2α Injections, Intra-Articular Male Matrix Metalloproteinase 13 - metabolism Mice, Inbred C57BL Nitric Oxide Synthase Type II - metabolism osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Osteoarthritis - prevention & control Phytotherapy Random Allocation resveratrol SIRT1 Sirtuin 1 - metabolism Stilbenes - pharmacology Stilbenes - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!