Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary
Aim The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and Methods Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2015-06, Vol.41 (6), p.926-931 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Keskin Kurt, Raziye Dogan, Ayşe Citil Dogan, Murat Albayrak, Aynur Kurt, Sefika Nur Eren, Furkan Silfeler, Dilek Benk Karateke, Atilla Fadillioglu, Ersin Delibasi, Tuncay |
| description | Aim
The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.
Material and Methods
Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion–detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion–detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion–detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion–detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl.
Results
Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group.
Conclusion
Our study results revealed that zofenopril attenuates injury induced by ischemia‐reperfusion on rat ovary. |
| doi_str_mv | 10.1111/jog.12658 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1685751261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1685751261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3878-3f134b18bd9e3ebbee30a1150e5b6c1f2c95492ffc9b250fdf5be0dd339743983</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqVw4AVQjnBIa8dx7BxRRUtR1SLxJ3Gx7GQNKWlS7ATo22Mo7Y3VSruHb0ezg9ApwX3ia7CoX_okSpjYQ10SxzzEnCX7fqcxCQXmSQcdObfAmPCUiEPUiRiLE8pFF02eawNVvbJFGaimgapVDbigqBatXfuRtxnkgfary15hWajQwgqsaV1RV4Fvq5qg_lB2fYwOjCodnPzNHnoYXd0Pr8PpfDwZXk7DjAouQmq8K02EzlOgoDUAxYoQhoHpJCMmylIWp5ExWaojhk1umAac55SmPKapoD10vtFd2fq9BdfIpfcGZakqqFsnSSIYZz4O4tGLDZrZ2jkLRvo_l96rJFj-JCd9cvI3Oc-e_cm2egn5jtxG5YHBBvgsSlj_ryRv5uOtZLi5KFwDX7sLZd9kwiln8mk2lvxuhGePt0wO6Tcuwofc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685751261</pqid></control><display><type>article</type><title>Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Keskin Kurt, Raziye ; Dogan, Ayşe Citil ; Dogan, Murat ; Albayrak, Aynur ; Kurt, Sefika Nur ; Eren, Furkan ; Silfeler, Dilek Benk ; Karateke, Atilla ; Fadillioglu, Ersin ; Delibasi, Tuncay</creator><creatorcontrib>Keskin Kurt, Raziye ; Dogan, Ayşe Citil ; Dogan, Murat ; Albayrak, Aynur ; Kurt, Sefika Nur ; Eren, Furkan ; Silfeler, Dilek Benk ; Karateke, Atilla ; Fadillioglu, Ersin ; Delibasi, Tuncay</creatorcontrib><description>Aim
The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.
Material and Methods
Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion–detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion–detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion–detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion–detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl.
Results
Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group.
Conclusion
Our study results revealed that zofenopril attenuates injury induced by ischemia‐reperfusion on rat ovary.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.12658</identifier><identifier>PMID: 25546378</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject><![CDATA[Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; antioxidant ; Antioxidants - administration & dosage ; Antioxidants - therapeutic use ; Biomarkers - metabolism ; Captopril - administration & dosage ; Captopril - analogs & derivatives ; Captopril - therapeutic use ; Catalase - antagonists & inhibitors ; Catalase - metabolism ; Dose-Response Relationship, Drug ; Female ; ischemia-reperfusion injury ; Malondialdehyde - antagonists & inhibitors ; Malondialdehyde - metabolism ; Ovarian Diseases - etiology ; Ovarian Diseases - metabolism ; Ovarian Diseases - pathology ; Ovarian Diseases - prevention & control ; ovarian torsion ; Ovary - blood supply ; Ovary - drug effects ; Ovary - metabolism ; Ovary - pathology ; Oxidative Stress - drug effects ; Protein Carbonylation - drug effects ; Random Allocation ; Rats, Wistar ; Reperfusion Injury - etiology ; Reperfusion Injury - metabolism ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Torsion, Mechanical ; zofenopril]]></subject><ispartof>The journal of obstetrics and gynaecology research, 2015-06, Vol.41 (6), p.926-931</ispartof><rights>2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology</rights><rights>2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3878-3f134b18bd9e3ebbee30a1150e5b6c1f2c95492ffc9b250fdf5be0dd339743983</citedby><cites>FETCH-LOGICAL-c3878-3f134b18bd9e3ebbee30a1150e5b6c1f2c95492ffc9b250fdf5be0dd339743983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.12658$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.12658$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25546378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keskin Kurt, Raziye</creatorcontrib><creatorcontrib>Dogan, Ayşe Citil</creatorcontrib><creatorcontrib>Dogan, Murat</creatorcontrib><creatorcontrib>Albayrak, Aynur</creatorcontrib><creatorcontrib>Kurt, Sefika Nur</creatorcontrib><creatorcontrib>Eren, Furkan</creatorcontrib><creatorcontrib>Silfeler, Dilek Benk</creatorcontrib><creatorcontrib>Karateke, Atilla</creatorcontrib><creatorcontrib>Fadillioglu, Ersin</creatorcontrib><creatorcontrib>Delibasi, Tuncay</creatorcontrib><title>Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.
Material and Methods
Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion–detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion–detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion–detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion–detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl.
Results
Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group.
Conclusion
Our study results revealed that zofenopril attenuates injury induced by ischemia‐reperfusion on rat ovary.</description><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>antioxidant</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - therapeutic use</subject><subject>Biomarkers - metabolism</subject><subject>Captopril - administration & dosage</subject><subject>Captopril - analogs & derivatives</subject><subject>Captopril - therapeutic use</subject><subject>Catalase - antagonists & inhibitors</subject><subject>Catalase - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>ischemia-reperfusion injury</subject><subject>Malondialdehyde - antagonists & inhibitors</subject><subject>Malondialdehyde - metabolism</subject><subject>Ovarian Diseases - etiology</subject><subject>Ovarian Diseases - metabolism</subject><subject>Ovarian Diseases - pathology</subject><subject>Ovarian Diseases - prevention & control</subject><subject>ovarian torsion</subject><subject>Ovary - blood supply</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>Oxidative Stress - drug effects</subject><subject>Protein Carbonylation - drug effects</subject><subject>Random Allocation</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Torsion, Mechanical</subject><subject>zofenopril</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OwzAQhC0EoqVw4AVQjnBIa8dx7BxRRUtR1SLxJ3Gx7GQNKWlS7ATo22Mo7Y3VSruHb0ezg9ApwX3ia7CoX_okSpjYQ10SxzzEnCX7fqcxCQXmSQcdObfAmPCUiEPUiRiLE8pFF02eawNVvbJFGaimgapVDbigqBatXfuRtxnkgfary15hWajQwgqsaV1RV4Fvq5qg_lB2fYwOjCodnPzNHnoYXd0Pr8PpfDwZXk7DjAouQmq8K02EzlOgoDUAxYoQhoHpJCMmylIWp5ExWaojhk1umAac55SmPKapoD10vtFd2fq9BdfIpfcGZakqqFsnSSIYZz4O4tGLDZrZ2jkLRvo_l96rJFj-JCd9cvI3Oc-e_cm2egn5jtxG5YHBBvgsSlj_ryRv5uOtZLi5KFwDX7sLZd9kwiln8mk2lvxuhGePt0wO6Tcuwofc</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Keskin Kurt, Raziye</creator><creator>Dogan, Ayşe Citil</creator><creator>Dogan, Murat</creator><creator>Albayrak, Aynur</creator><creator>Kurt, Sefika Nur</creator><creator>Eren, Furkan</creator><creator>Silfeler, Dilek Benk</creator><creator>Karateke, Atilla</creator><creator>Fadillioglu, Ersin</creator><creator>Delibasi, Tuncay</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary</title><author>Keskin Kurt, Raziye ; Dogan, Ayşe Citil ; Dogan, Murat ; Albayrak, Aynur ; Kurt, Sefika Nur ; Eren, Furkan ; Silfeler, Dilek Benk ; Karateke, Atilla ; Fadillioglu, Ersin ; Delibasi, Tuncay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3878-3f134b18bd9e3ebbee30a1150e5b6c1f2c95492ffc9b250fdf5be0dd339743983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>antioxidant</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - therapeutic use</topic><topic>Biomarkers - metabolism</topic><topic>Captopril - administration & dosage</topic><topic>Captopril - analogs & derivatives</topic><topic>Captopril - therapeutic use</topic><topic>Catalase - antagonists & inhibitors</topic><topic>Catalase - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>ischemia-reperfusion injury</topic><topic>Malondialdehyde - antagonists & inhibitors</topic><topic>Malondialdehyde - metabolism</topic><topic>Ovarian Diseases - etiology</topic><topic>Ovarian Diseases - metabolism</topic><topic>Ovarian Diseases - pathology</topic><topic>Ovarian Diseases - prevention & control</topic><topic>ovarian torsion</topic><topic>Ovary - blood supply</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Ovary - pathology</topic><topic>Oxidative Stress - drug effects</topic><topic>Protein Carbonylation - drug effects</topic><topic>Random Allocation</topic><topic>Rats, Wistar</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Torsion, Mechanical</topic><topic>zofenopril</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keskin Kurt, Raziye</creatorcontrib><creatorcontrib>Dogan, Ayşe Citil</creatorcontrib><creatorcontrib>Dogan, Murat</creatorcontrib><creatorcontrib>Albayrak, Aynur</creatorcontrib><creatorcontrib>Kurt, Sefika Nur</creatorcontrib><creatorcontrib>Eren, Furkan</creatorcontrib><creatorcontrib>Silfeler, Dilek Benk</creatorcontrib><creatorcontrib>Karateke, Atilla</creatorcontrib><creatorcontrib>Fadillioglu, Ersin</creatorcontrib><creatorcontrib>Delibasi, Tuncay</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keskin Kurt, Raziye</au><au>Dogan, Ayşe Citil</au><au>Dogan, Murat</au><au>Albayrak, Aynur</au><au>Kurt, Sefika Nur</au><au>Eren, Furkan</au><au>Silfeler, Dilek Benk</au><au>Karateke, Atilla</au><au>Fadillioglu, Ersin</au><au>Delibasi, Tuncay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2015-06</date><risdate>2015</risdate><volume>41</volume><issue>6</issue><spage>926</spage><epage>931</epage><pages>926-931</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.
Material and Methods
Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n = 7); vehicle group 1 (torsion–detorsion, n = 7) with 2 h ischemia and 2 h reperfusion; vehicle group 2 (torsion–detorsion, n = 7) with 2 h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion–detorsion, n = 7) with 2 h ischemia, 2 h reperfusion and a signal dose of oral 15 mg/kg zofenopril; and zofenopril group 2 (torsion–detorsion, n = 7) with 2 h ischemia, 5 days' reperfusion and 5 days' oral 15 mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl.
Results
Compared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group.
Conclusion
Our study results revealed that zofenopril attenuates injury induced by ischemia‐reperfusion on rat ovary.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25546378</pmid><doi>10.1111/jog.12658</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2015-06, Vol.41 (6), p.926-931 |
| issn | 1341-8076 1447-0756 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals antioxidant Antioxidants - administration & dosage Antioxidants - therapeutic use Biomarkers - metabolism Captopril - administration & dosage Captopril - analogs & derivatives Captopril - therapeutic use Catalase - antagonists & inhibitors Catalase - metabolism Dose-Response Relationship, Drug Female ischemia-reperfusion injury Malondialdehyde - antagonists & inhibitors Malondialdehyde - metabolism Ovarian Diseases - etiology Ovarian Diseases - metabolism Ovarian Diseases - pathology Ovarian Diseases - prevention & control ovarian torsion Ovary - blood supply Ovary - drug effects Ovary - metabolism Ovary - pathology Oxidative Stress - drug effects Protein Carbonylation - drug effects Random Allocation Rats, Wistar Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Torsion, Mechanical zofenopril |
| title | Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary |
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