An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA

The leading risk factor for gastric cancer in humans is infection by Helicobacter pylori strains that express and translocate the oncoprotein CagA into host epithelial cells. Once inside host cells, CagA interacts with ASPP2, which specifically stimulates p53-mediated apoptosis and reverses its pro-...

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Veröffentlicht in:	Biochemistry (Easton) 2015-06, Vol.54 (21), p.3337-3347
Hauptverfasser:	Reingewertz, Tali H, Iosub-Amir, Anat, Bonsor, Daniel A, Mayer, Guy, Amartely, Hadar, Friedler, Assaf, Sundberg, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - chemistry Antigens, Bacterial - metabolism Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Helicobacter Infections - complications Helicobacter pylori - metabolism Humans Models, Molecular Protein Binding Protein Interaction Domains and Motifs Stomach Neoplasms - etiology Stomach Neoplasms - microbiology
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