Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody–Drug Conjugate

The use of predictive preclinical models in drug discovery is critical for compound selection, optimization, preclinical to clinical translation, and strategic decision-making. Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in cli...

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Veröffentlicht in:	Molecular pharmaceutics 2015-06, Vol.12 (6), p.1730-1737
Hauptverfasser:	Hu, George, Leal, Mauricio, Lin, Qingcong, Affolter, Timothy, Sapra, Puja, Bates, Brian, Damelin, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - pharmacokinetics Humans Immunoconjugates - pharmacokinetics Immunohistochemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Transgenic Phenotype
Online-Zugang:	Volltext
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