Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2

The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show that cyclin-dependent kinase 5 (Cdk5) is an e...

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Veröffentlicht in:	Nature communications 2015-06, Vol.6 (1), p.7274-7274, Article 7274
Hauptverfasser:	Liebl, Johanna, Zhang, Siwei, Moser, Markus, Agalarov, Yan, Demir, Cansaran Saygili, Hager, Bianca, Bibb, James A., Adams, Ralf H., Kiefer, Friedemann, Miura, Naoyuki, Petrova, Tatiana V., Vollmar, Angelika M., Zahler, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 14 14/19 42/89 631/136/1660/1993 631/136/290 631/80/458/1733 631/80/86 64/110 Animals Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Lymphangiogenesis - genetics Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Mice Mice, Knockout multidisciplinary Phosphorylation Real-Time Polymerase Chain Reaction Science Science (multidisciplinary) Stress, Mechanical
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