Genome sequence analysis of Ebola virus in clinical samples from three British healthcare workers, August 2014 to March 2015

We determined complete viral genome sequences from three British healthcare workers infected with Ebola virus (EBOV) in Sierra Leone, directly from clinical samples. These sequences closely resemble those previously observed in the current Ebola virus disease outbreak in West Africa, with glycoprote...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2015-05, Vol.20 (20), p.1
Hauptverfasser:	Bell, A, Lewandowski, K, Myers, R, Wooldridge, D, Aarons, E, Simpson, A, Vipond, R, Jacobs, M, Gharbia, S, Zambon, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Disease Outbreaks Ebola virus Ebolavirus - genetics Ebolavirus - isolation & purification Epidemics Genes Genome, Viral - genetics Genomes Glycoproteins Health Personnel Hemorrhagic Fever, Ebola - diagnosis Humans Medical personnel Phylogeny Polymerase chain reaction Sequence Analysis Sierra Leone - epidemiology Travel
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Zusammenfassung:	We determined complete viral genome sequences from three British healthcare workers infected with Ebola virus (EBOV) in Sierra Leone, directly from clinical samples. These sequences closely resemble those previously observed in the current Ebola virus disease outbreak in West Africa, with glycoprotein and polymerase genes showing the most sequence variation. Our data indicate that current PCR diagnostic assays remain suitable for detection of EBOV in this epidemic and provide confidence for their continued use in diagnosis.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES2015.20.20.21131