Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease
In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not remove...
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| Veröffentlicht in: | Acta neuropathologica 1995, Vol.89 (4), p.291-295 |
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| container_title | Acta neuropathologica |
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| creator | Cras, P Smith, M A Richey, P L Siedlak, S L Mulvihill, P Perry, G |
| description | In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not removed from the brain throughout the disease process. This finding, together with our previous demonstration of carbonyl-related modifications in NFT, provides additional evidence that the protein constituents of NFT are resistant to proteolytic removal, possibly as a result of extensive cross-links. Additionally, correlation between the number of NFT and neuronal loss indicates that there are at least two distinct mechanisms responsible for neuronal death in Alzheimer's disease that are directly and indirectly related to the presence of neurofibrillary pathology. |
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| ispartof | Acta neuropathologica, 1995, Vol.89 (4), p.291-295 |
| issn | 0001-6322 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Alzheimer Disease - pathology Cell Count Cell Death Entorhinal Cortex - pathology Frontal Lobe - pathology Humans Microglia - pathology Middle Aged Neurofibrillary Tangles - pathology |
| title | Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease |
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