Use of isotopically chiral [4'- super(13)C]penciclovir and super(13)C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1- and HSV-2-infected cells and by HSV-1-encoded thymidine kinase

Penciclovir is a potent antiherpesvirus agent which is highly selective due to its phosphorylation only in virus infected cells. Phosphorylation of one of the hydroxymethyl groups of penciclovir (PCV) creates a chiral centre leading to the possible formation of (R)- and (S)-enantiomers. The absolute...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1993-01, Vol.5 (8), p.583-588
Hauptverfasser:	Vere Hodge, RA, Darlison, S J, Earnshaw, D L, Readshaw, SA
Format:	Artikel
Sprache:	eng
Schlagworte:	herpes simplex virus 1 herpes simplex virus 2
Online-Zugang:	Volltext
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