Regional specificity of membrane instability in Alzheimer's disease brain

We report an inherent tendency towards the destabilisation of cellular membranes in Alzheimer's disease (AD) brain. This tendency is a natural consequence of abnormal membrane lipid composition, which has previously been documented in AD. Membrane destabilisation may contribute to AD pathogenes...

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Veröffentlicht in:	Brain research 1993-07, Vol.615 (2), p.355-357
Hauptverfasser:	Ginsberg, Lionel, Atack, John R., Rapoport, Stanley I., Gershfeld, Norman L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Brain - metabolism Brain - pathology Cell Membrane - metabolism Cell Membrane - physiology Critical temperature Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Lipid bilayer instability Male Medical sciences Membrane Membrane Lipids - metabolism Nerve Degeneration Neurodegeneration Neurology Temperature
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