Localization of a Putative Tumor Suppressor Gene by Using Homozygous Deletions in Melanomas

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have bee...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-08, Vol.91 (16), p.7563-7567
Hauptverfasser:	Weaver-Feldhaus, J, Gruis, N A, Neuhausen, S, Le Paslier, D, Stockert, E, Skolnick, M H, Kamb, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell lines chromosome 9 Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 9 Cloning, Molecular Cosmids DNA Genes Genes, Tumor Suppressor - genetics Genetic Linkage Genetic Markers Genetics Genomics Homozygote Humans man Medical research Melanoma Melanoma - genetics MLM gene Sequence Deletion Sequence Tagged Sites Tumor cell line Tumor Cells, Cultured tumor suppressor genes Tumors
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