Molecular Cloning, Expression, and Partial Characterization of a Second Human Tissue-Factor-Pathway Inhibitor

Previous studies have shown that tissue-factor-pathway inhibitor (TFPI) is an important regulator of the extrinsic pathway of blood coagulation through its ability to inhibit factor Xa and factor VIIa-tissue factor activity. We describe the molecular cloning and expression of a full-length cDNA that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (8), p.3353-3357
Hauptverfasser:	SPRECHER, C. A, KISIEL, W, MATHEWES, S, FOSTER, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Base Sequence Basic amino acids Biochemistry Biological and medical sciences Blood Blood coagulation. Blood cells cDNA Cloning, Molecular coagulation Coagulation factors Complementary DNA DNA, Complementary - genetics Endothelial cells expression Factor VIIa - antagonists & inhibitors Fundamental and applied biological sciences. Psychology Genes Glycoproteins - genetics Glycoproteins - pharmacology Heparin Heparin - pharmacology Humans Lipoproteins - genetics Lipoproteins - pharmacology man Messenger RNA Molecular and cellular biology Molecular cloning Molecular Sequence Data Molecular Weight Molecules nucleotide sequence Placenta predictions Pregnancy Proteins - genetics Pregnancy Proteins - pharmacology properties Protein Structure, Secondary Proteins Sequence Alignment Sequence Homology, Amino Acid tissue-factor-pathway inhibitor 2
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