Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review

Up to 90% of all cancers are possibly caused by environmental factors, such as tobacco smoke, diet and occupational exposures. The majority of chemical carcinogens require metabolic activation before they interact with cellular macromolecules and can cause cancer initiation. The xenobiotic-metabolis...

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Veröffentlicht in:	Gene 1995-06, Vol.159 (1), p.113-121
Hauptverfasser:	Raunio, Hannu, Husgafvel-Pursiainen, Kirsti, Anttila, Sisko, Hietanen, Eino, Hirvonen, Ari, Pelkonen, Olavi
Format:	Artikel
Sprache:	eng
Schlagworte:	Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Biotransformation Carcinogens - pharmacology cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Disease Susceptibility Environmental factors Enzymes - genetics Glutathione Transferase - genetics Glutathione Transferase - metabolism Humans modifiers Neoplasms - enzymology Neoplasms - genetics Polymorphism, Restriction Fragment Length RFLP tobacco smoke Xenobiotics - metabolism
Online-Zugang:	Volltext
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