Structure-mutagenicity relationships of four amino-imidazonaphthyridines and imidazoquinolines

We tested four isomeric imidazonaphthyridines and one imidazoquinoline compound for mutagenic activity in the Ames/Salmonella mutagenicity assay, using strain TA98 and strain YG1024, an analogue of strain TA98 with elevated O‐acetyl‐transferase levels. Their potency was related to calculated electro...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1995, Vol.26 (1), p.79-85
Hauptverfasser:	Vikse, R., Hatch, F. T., Winter, N. W., Knize, M. G., Grivas, S., Felton, J. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ames test aminoimidazo-azaarenes aromatic amines Biological and medical sciences Chemical mutagenesis Dose-Response Relationship, Drug Imidazoles - chemistry Imidazoles - pharmacology Medical sciences Molecular Structure Mutagenicity Tests Mutagens - chemistry Mutagens - pharmacology Naphthyridines - chemistry Naphthyridines - pharmacology Quinolines - chemistry Quinolines - pharmacology Salmonella mutagenicity Salmonella typhimurium Salmonella typhimurium - drug effects Structure-Activity Relationship structure/activity Toxicology YG1024
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