The effect of multiple doses of ranitidine on the pharmacokinetics and metabolism of diltiazem in dogs

In order to determine the potential pharmacokinetic drug interaction between ranitidine and diltiazem (DTZ), each of ten male beagle dogs, age 2·7–4·0 years, weight 13–16 kg, received a single oral dose of sustained release DTZ with and without previous multiple oral doses of ranitidine (150 mg bid...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1994-04, Vol.15 (3), p.207-215
Hauptverfasser:	Yeung, Pollen K. F., Mosher, Susan J., Landriault, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Chromatography, High Pressure Liquid Diltiazem Diltiazem - blood Diltiazem - metabolism Diltiazem - pharmacokinetics Dogs Drug Interactions Interactions Male Medical sciences Pharmacokinetics Pharmacology. Drug treatments Ranitidine Ranitidine - pharmacology
Online-Zugang:	Volltext
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