Correlation of Merkel cell polyomavirus positivity with PDGFRα mutations and survivin expression in Merkel cell carcinoma

Highlights • Polyomavirus positivity or integration do not correlate to disease outcome. • Higher viral load are associated with progressive disease, suggesting the viral load as indicator of disease progression. • In MCC we found PDGFRα and TP53 gene mutations, but not in BRAF and KIT. • We identif...

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Veröffentlicht in:	Journal of dermatological science 2015-07, Vol.79 (1), p.43-49
Hauptverfasser:	Batinica, M, Akgül, B, Silling, S, Mauch, C, Zigrino, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Merkel Cell - chemistry Carcinoma, Merkel Cell - genetics Carcinoma, Merkel Cell - virology Dermatology Disease Progression Female Genes, p53 Humans Inhibitor of Apoptosis Proteins - analysis Inhibitor of Apoptosis Proteins - metabolism Male Merkel cell carcinoma Merkel cell polyomavirus Merkel cell polyomavirus - isolation & purification Mutations PDGFR Polymorphism, Single Nucleotide Receptor, Platelet-Derived Growth Factor alpha - analysis Receptor, Platelet-Derived Growth Factor alpha - genetics Skin Neoplasms - chemistry Skin Neoplasms - genetics Skin Neoplasms - virology Viral Load Virus Integration
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Zusammenfassung:	Highlights • Polyomavirus positivity or integration do not correlate to disease outcome. • Higher viral load are associated with progressive disease, suggesting the viral load as indicator of disease progression. • In MCC we found PDGFRα and TP53 gene mutations, but not in BRAF and KIT. • We identified new mutations in the PDGFRα, but none in the TP53.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2015.04.002