Ketamine modulates TRH and TRH-like peptide turnover in brain and peripheral tissues of male rats

•TRH and TRH-like peptides increase throughout limbic system 1h after ketamine.•This increase may be due to increased ascorbate-dependent synthesis of TRH-like peptides.•Glu-TRH increased levels of TRH-like peptides via competitive inhibition of degrading enzymes.•Anxiolytic effects of ketamine may...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2015-07, Vol.69, p.66-76
Hauptverfasser:	Pekary, A. Eugene, Sattin, Albert, Lloyd, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Brain - drug effects Brain - metabolism Brain - physiopathology Depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Humans Ketamine - administration & dosage Ketamine - metabolism Limbic system Male N-Methylaspartate - antagonists & inhibitors N-Methylaspartate - metabolism Neuroendocrine Peptides - metabolism Rats Rats, Sprague-Dawley Suicide Thyrotropin-Releasing Hormone - biosynthesis Thyrotropin-Releasing Hormone - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!