Survival Benefit of Surgical Treatment for Liver Metastases from Gastric Cancer
Background and Objectives Indications for the resection of liver metastases from gastric cancers (GLM) remain controversial, and few previous studies have reported subsequent surgical outcomes. Thus, the present retrospective study was designed to clarify the benefits of surgical treatment and ident...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2015-06, Vol.19 (6), p.1043-1051 |
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| creator | Shinohara, Toshiki Maeda, Yoshiaki Hamada, Tomonori Futakawa, Noriaki |
| description | Background and Objectives
Indications for the resection of liver metastases from gastric cancers (GLM) remain controversial, and few previous studies have reported subsequent surgical outcomes. Thus, the present retrospective study was designed to clarify the benefits of surgical treatment and identify prognostic factors.
Methods
Outcomes of 47 patients with or without hepatectomy for GLM were retrospectively compared.
Results
A total of 22 patients received surgical treatment for GLM, and overall 1-, 3-, and 5-year survival rates were 86, 26, and 26 %, respectively, and the median survival time (MST) was 22 months. Among 25 patients who did not receive hepatic surgical treatment, the overall survival rates were 24, 8.0, and 4.0 % at 1-, 3-, and 5-years, respectively, with an MST of 7 months. A significant difference was observed between patients with and without the liver surgical treatment (
P
|
| doi_str_mv | 10.1007/s11605-015-2775-6 |
| format | Article |
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Indications for the resection of liver metastases from gastric cancers (GLM) remain controversial, and few previous studies have reported subsequent surgical outcomes. Thus, the present retrospective study was designed to clarify the benefits of surgical treatment and identify prognostic factors.
Methods
Outcomes of 47 patients with or without hepatectomy for GLM were retrospectively compared.
Results
A total of 22 patients received surgical treatment for GLM, and overall 1-, 3-, and 5-year survival rates were 86, 26, and 26 %, respectively, and the median survival time (MST) was 22 months. Among 25 patients who did not receive hepatic surgical treatment, the overall survival rates were 24, 8.0, and 4.0 % at 1-, 3-, and 5-years, respectively, with an MST of 7 months. A significant difference was observed between patients with and without the liver surgical treatment (
P
< 0.001). Univariate and multivariate analyses of recipients of surgery, only the number of liver metastases (solitary or multiple) was significantly predictive of survival (HR = 0.26,
P
= 0.029) following hepatic resection for GLM.
Conclusions
Surgical treatment of GLM should be considered when complete excision including the primary tumor appears to be possible, particularly in cases of solitary hepatic metastases.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-015-2775-6</identifier><identifier>PMID: 25693424</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenocarcinoma - secondary ; Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Cancer therapies ; Chemotherapy ; Female ; Gastric cancer ; Gastroenterology ; Hepatectomy ; Hepatectomy - methods ; Hepatectomy - mortality ; Humans ; Japan - epidemiology ; Liver ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Lymphatic system ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Metastasis ; Original Article ; Prognosis ; Retrospective Studies ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Surgical outcomes ; Survival Rate - trends</subject><ispartof>Journal of gastrointestinal surgery, 2015-06, Vol.19 (6), p.1043-1051</ispartof><rights>The Society for Surgery of the Alimentary Tract 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-7e558a480ac21395cb7e56fadb95a23c6d2ac453a3f9232c249f6915880d41923</citedby><cites>FETCH-LOGICAL-c471t-7e558a480ac21395cb7e56fadb95a23c6d2ac453a3f9232c249f6915880d41923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-015-2775-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-015-2775-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25693424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinohara, Toshiki</creatorcontrib><creatorcontrib>Maeda, Yoshiaki</creatorcontrib><creatorcontrib>Hamada, Tomonori</creatorcontrib><creatorcontrib>Futakawa, Noriaki</creatorcontrib><title>Survival Benefit of Surgical Treatment for Liver Metastases from Gastric Cancer</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background and Objectives
Indications for the resection of liver metastases from gastric cancers (GLM) remain controversial, and few previous studies have reported subsequent surgical outcomes. Thus, the present retrospective study was designed to clarify the benefits of surgical treatment and identify prognostic factors.
Methods
Outcomes of 47 patients with or without hepatectomy for GLM were retrospectively compared.
Results
A total of 22 patients received surgical treatment for GLM, and overall 1-, 3-, and 5-year survival rates were 86, 26, and 26 %, respectively, and the median survival time (MST) was 22 months. Among 25 patients who did not receive hepatic surgical treatment, the overall survival rates were 24, 8.0, and 4.0 % at 1-, 3-, and 5-years, respectively, with an MST of 7 months. A significant difference was observed between patients with and without the liver surgical treatment (
P
< 0.001). Univariate and multivariate analyses of recipients of surgery, only the number of liver metastases (solitary or multiple) was significantly predictive of survival (HR = 0.26,
P
= 0.029) following hepatic resection for GLM.
Conclusions
Surgical treatment of GLM should be considered when complete excision including the primary tumor appears to be possible, particularly in cases of solitary hepatic metastases.</description><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Hepatectomy - mortality</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Liver</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Survival Rate - trends</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM1KAzEUhYMotlYfwI0E3LiJ5n8ySy1ahUoXVnAX0kxSpnRmajJT8O1NnSoiCIHknnz33MsB4Jzga4JxdhMJkVggTASiWSaQPABDojKGuKTyML1xThAV4m0ATmJcYUwyTNQxGFAhc8YpH4LZSxe25das4Z2rnS9b2HiYtGVpkzYPzrSVq1vomwCn5dYF-OxaE9NxEfrQVHCSqlBaODa1deEUHHmzju5sf4_A68P9fPyIprPJ0_h2iizPSIsyJ4QyXGFjKWG5sIukSG-KRS4MZVYW1FgumGE-p4xaynMvcyKUwgUnSRqBq953E5r3zsVWV2W0br02tWu6qIlUnDOazBN6-QddNV2o03ZflEyc2lGkp2xoYgzO600oKxM-NMF6l7bu09Ypbb1LW8vUc7F37haVK346vuNNAO2BmL7qpQu_Rv_r-glLSoiB</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Shinohara, Toshiki</creator><creator>Maeda, Yoshiaki</creator><creator>Hamada, Tomonori</creator><creator>Futakawa, Noriaki</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Survival Benefit of Surgical Treatment for Liver Metastases from Gastric Cancer</title><author>Shinohara, Toshiki ; Maeda, Yoshiaki ; Hamada, Tomonori ; Futakawa, Noriaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-7e558a480ac21395cb7e56fadb95a23c6d2ac453a3f9232c249f6915880d41923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Hepatectomy - mortality</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Liver</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Survival Rate - trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinohara, Toshiki</creatorcontrib><creatorcontrib>Maeda, Yoshiaki</creatorcontrib><creatorcontrib>Hamada, Tomonori</creatorcontrib><creatorcontrib>Futakawa, Noriaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinohara, Toshiki</au><au>Maeda, Yoshiaki</au><au>Hamada, Tomonori</au><au>Futakawa, Noriaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival Benefit of Surgical Treatment for Liver Metastases from Gastric Cancer</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>19</volume><issue>6</issue><spage>1043</spage><epage>1051</epage><pages>1043-1051</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background and Objectives
Indications for the resection of liver metastases from gastric cancers (GLM) remain controversial, and few previous studies have reported subsequent surgical outcomes. Thus, the present retrospective study was designed to clarify the benefits of surgical treatment and identify prognostic factors.
Methods
Outcomes of 47 patients with or without hepatectomy for GLM were retrospectively compared.
Results
A total of 22 patients received surgical treatment for GLM, and overall 1-, 3-, and 5-year survival rates were 86, 26, and 26 %, respectively, and the median survival time (MST) was 22 months. Among 25 patients who did not receive hepatic surgical treatment, the overall survival rates were 24, 8.0, and 4.0 % at 1-, 3-, and 5-years, respectively, with an MST of 7 months. A significant difference was observed between patients with and without the liver surgical treatment (
P
< 0.001). Univariate and multivariate analyses of recipients of surgery, only the number of liver metastases (solitary or multiple) was significantly predictive of survival (HR = 0.26,
P
= 0.029) following hepatic resection for GLM.
Conclusions
Surgical treatment of GLM should be considered when complete excision including the primary tumor appears to be possible, particularly in cases of solitary hepatic metastases.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25693424</pmid><doi>10.1007/s11605-015-2775-6</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenocarcinoma - secondary Adenocarcinoma - surgery Adult Aged Aged, 80 and over Cancer therapies Chemotherapy Female Gastric cancer Gastroenterology Hepatectomy Hepatectomy - methods Hepatectomy - mortality Humans Japan - epidemiology Liver Liver Neoplasms - secondary Liver Neoplasms - surgery Lymphatic system Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Metastasis Original Article Prognosis Retrospective Studies Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Surgical outcomes Survival Rate - trends |
| title | Survival Benefit of Surgical Treatment for Liver Metastases from Gastric Cancer |
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