Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs
This study of U.S. neonatal intensive care units from 2004 through 2013 showed a substantial increase over time in admissions for the neonatal abstinence syndrome and increases in associated length of stay and the percentage of NICU days nationwide attributed to the syndrome. The neonatal abstinence...
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| Veröffentlicht in: | The New England journal of medicine 2015-05, Vol.372 (22), p.2118-2126 |
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| container_title | The New England journal of medicine |
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| creator | Tolia, Veeral N Patrick, Stephen W Bennett, Monica M Murthy, Karna Sousa, John Smith, P. Brian Clark, Reese H Spitzer, Alan R |
| description | This study of U.S. neonatal intensive care units from 2004 through 2013 showed a substantial increase over time in admissions for the neonatal abstinence syndrome and increases in associated length of stay and the percentage of NICU days nationwide attributed to the syndrome.
The neonatal abstinence syndrome is a drug-withdrawal syndrome that most commonly occurs after in utero exposure to opioids. It typically manifests in the first few days of life as hypertonia, autonomic instability, irritability, poor sucking reflex, impaired weight gain, and less commonly, seizures.
1
From 2000 through 2009, the incidence of the neonatal abstinence syndrome in the United States nearly tripled,
2
with several states reporting even larger recent increases.
3
,
4
This rise occurred in association with an increase in the use of opioids by pregnant women.
5
–
8
Despite the increased incidence of the neonatal abstinence syndrome, data on changes in the . . . |
| doi_str_mv | 10.1056/NEJMsa1500439 |
| format | Article |
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The neonatal abstinence syndrome is a drug-withdrawal syndrome that most commonly occurs after in utero exposure to opioids. It typically manifests in the first few days of life as hypertonia, autonomic instability, irritability, poor sucking reflex, impaired weight gain, and less commonly, seizures.
1
From 2000 through 2009, the incidence of the neonatal abstinence syndrome in the United States nearly tripled,
2
with several states reporting even larger recent increases.
3
,
4
This rise occurred in association with an increase in the use of opioids by pregnant women.
5
–
8
Despite the increased incidence of the neonatal abstinence syndrome, data on changes in the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMsa1500439</identifier><identifier>PMID: 25913111</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Cohort Studies ; Cross-Sectional Studies ; Data processing ; Datasets as Topic ; Drug withdrawal ; Gestational Age ; Health Resources - trends ; Health Resources - utilization ; Humans ; Incidence ; Infant, Newborn ; Infants ; Intensive care ; Intensive care units ; Intensive Care Units, Neonatal - utilization ; Intrauterine exposure ; Length of Stay - trends ; Morbidity ; Morphine ; Narcotics ; Neonatal abstinence syndrome ; Neonatal Abstinence Syndrome - epidemiology ; Neonates ; Newborn babies ; Opioids ; Patient Admission - trends ; United States - epidemiology</subject><ispartof>The New England journal of medicine, 2015-05, Vol.372 (22), p.2118-2126</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a457t-8d3d65978d215cb0d53fc8bf7e31a338eb0f15aa0b745d9076f4fa1c55feb4de3</citedby><cites>FETCH-LOGICAL-a457t-8d3d65978d215cb0d53fc8bf7e31a338eb0f15aa0b745d9076f4fa1c55feb4de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMsa1500439$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1683979823?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,2745,2746,26082,27903,27904,52361,54043,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25913111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolia, Veeral N</creatorcontrib><creatorcontrib>Patrick, Stephen W</creatorcontrib><creatorcontrib>Bennett, Monica M</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Sousa, John</creatorcontrib><creatorcontrib>Smith, P. Brian</creatorcontrib><creatorcontrib>Clark, Reese H</creatorcontrib><creatorcontrib>Spitzer, Alan R</creatorcontrib><title>Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This study of U.S. neonatal intensive care units from 2004 through 2013 showed a substantial increase over time in admissions for the neonatal abstinence syndrome and increases in associated length of stay and the percentage of NICU days nationwide attributed to the syndrome.
The neonatal abstinence syndrome is a drug-withdrawal syndrome that most commonly occurs after in utero exposure to opioids. It typically manifests in the first few days of life as hypertonia, autonomic instability, irritability, poor sucking reflex, impaired weight gain, and less commonly, seizures.
1
From 2000 through 2009, the incidence of the neonatal abstinence syndrome in the United States nearly tripled,
2
with several states reporting even larger recent increases.
3
,
4
This rise occurred in association with an increase in the use of opioids by pregnant women.
5
–
8
Despite the increased incidence of the neonatal abstinence syndrome, data on changes in the . . .</description><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Data processing</subject><subject>Datasets as Topic</subject><subject>Drug withdrawal</subject><subject>Gestational Age</subject><subject>Health Resources - trends</subject><subject>Health Resources - utilization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Intensive Care Units, Neonatal - utilization</subject><subject>Intrauterine exposure</subject><subject>Length of Stay - trends</subject><subject>Morbidity</subject><subject>Morphine</subject><subject>Narcotics</subject><subject>Neonatal abstinence syndrome</subject><subject>Neonatal Abstinence Syndrome - epidemiology</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Opioids</subject><subject>Patient Admission - trends</subject><subject>United States - epidemiology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10MFLwzAUBvAgipvTo1cpiOClM69J2uQ4xtSJzsPcuaTNi3as6Wzaw_57OzcVBXN5gffj4_ERcg50CFTEN7PJw5PXICjlTB2QPgjGQs5pfEj6lEYy5IliPXLi_ZJ2D7g6Jr1IKGAA0Cezqctr1L5wr0H3LQy6HIPKBs0bBjOsnG70Khhlvinc52q-caauSgwKFyyG8-EPmo4X_pQcWb3yeLafA7K4nbyM78PH57vpePQYai6SJpSGmVioRJoIRJ5RI5jNZWYTZKAZk5hRC0JrmiVcGEWT2HKrIRfCYsYNsgG53uWu6-q9Rd-kZeFzXK20w6r1KcSScwaKy45e_qHLqq1dd91WMZUoGbFOhTuV15X3Ndp0XRelrjcp0HRbdPqr6M5f7FPbrETzrb-a7cDVDpSlTx0uy3-CPgCY9IJd</recordid><startdate>20150528</startdate><enddate>20150528</enddate><creator>Tolia, Veeral N</creator><creator>Patrick, Stephen W</creator><creator>Bennett, Monica M</creator><creator>Murthy, Karna</creator><creator>Sousa, John</creator><creator>Smith, P. Brian</creator><creator>Clark, Reese H</creator><creator>Spitzer, Alan R</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150528</creationdate><title>Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs</title><author>Tolia, Veeral N ; Patrick, Stephen W ; Bennett, Monica M ; Murthy, Karna ; Sousa, John ; Smith, P. Brian ; Clark, Reese H ; Spitzer, Alan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a457t-8d3d65978d215cb0d53fc8bf7e31a338eb0f15aa0b745d9076f4fa1c55feb4de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Data processing</topic><topic>Datasets as Topic</topic><topic>Drug withdrawal</topic><topic>Gestational Age</topic><topic>Health Resources - trends</topic><topic>Health Resources - utilization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Intensive care units</topic><topic>Intensive Care Units, Neonatal - utilization</topic><topic>Intrauterine exposure</topic><topic>Length of Stay - trends</topic><topic>Morbidity</topic><topic>Morphine</topic><topic>Narcotics</topic><topic>Neonatal abstinence syndrome</topic><topic>Neonatal Abstinence Syndrome - epidemiology</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Opioids</topic><topic>Patient Admission - trends</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolia, Veeral N</creatorcontrib><creatorcontrib>Patrick, Stephen W</creatorcontrib><creatorcontrib>Bennett, Monica M</creatorcontrib><creatorcontrib>Murthy, Karna</creatorcontrib><creatorcontrib>Sousa, John</creatorcontrib><creatorcontrib>Smith, P. 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The neonatal abstinence syndrome is a drug-withdrawal syndrome that most commonly occurs after in utero exposure to opioids. It typically manifests in the first few days of life as hypertonia, autonomic instability, irritability, poor sucking reflex, impaired weight gain, and less commonly, seizures.
1
From 2000 through 2009, the incidence of the neonatal abstinence syndrome in the United States nearly tripled,
2
with several states reporting even larger recent increases.
3
,
4
This rise occurred in association with an increase in the use of opioids by pregnant women.
5
–
8
Despite the increased incidence of the neonatal abstinence syndrome, data on changes in the . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>25913111</pmid><doi>10.1056/NEJMsa1500439</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Cohort Studies Cross-Sectional Studies Data processing Datasets as Topic Drug withdrawal Gestational Age Health Resources - trends Health Resources - utilization Humans Incidence Infant, Newborn Infants Intensive care Intensive care units Intensive Care Units, Neonatal - utilization Intrauterine exposure Length of Stay - trends Morbidity Morphine Narcotics Neonatal abstinence syndrome Neonatal Abstinence Syndrome - epidemiology Neonates Newborn babies Opioids Patient Admission - trends United States - epidemiology |
| title | Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs |
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