Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance

Macrocyclic lactone (ML) endectocides are used as chemoprophylaxis for heartworm infection (Dirofilaria immitis) in dogs and cats. Claims of loss of efficacy (LOE) of ML heartworm preventives have become common in some locations in the USA. We directly tested whether resistance to MLs exists in LOE...

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Veröffentlicht in:	Veterinary parasitology 2015-06, Vol.210 (3-4), p.167-178
Hauptverfasser:	Bourguinat, Catherine, Lee, Alice C.Y., Lizundia, Regina, Blagburn, Byron L., Liotta, Janice L., Kraus, Marc S., Keller, Kathy, Epe, Christian, Letourneau, Louis, Kleinman, Claudia L., Paterson, Tara, Gomez, Elena Carreton, Montoya-Alonso, José Alberto, Smith, Hubert, Bhan, Aron, Peregrine, Andrew S., Carmichael, James, Drake, Jason, Schenker, Rudolf, Kaminsky, Ronald, Bowman, Dwight D., Geary, Timothy G., Prichard, Roger K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemoprevention - veterinary Dirofilaria immitis Dirofilaria immitis - drug effects Dirofilaria immitis - genetics Dirofilariasis - parasitology Dog Diseases - parasitology Dogs Drug Resistance Female Filaricides - pharmacology Genetic markers Genetic Markers - genetics Ivermectin Ivermectin - pharmacology Lactones - pharmacology Macrocyclic lactones Macrolides - pharmacology Male Microfilariae Moxidectin Polymorphism, Single Nucleotide - genetics Resistance
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