Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells

The receptor for advanced glycation end‐products (RAGE) is a multiligand member of the immunoglobulin superfamily, which plays an important role in maintaining cellular homeostasis. It is normally expressed on immune cells, including macrophages, monocytes, dendritic cells and T cells to maintain ho...

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Veröffentlicht in:	IUBMB life 2015-05, Vol.67 (5), p.361-373
Hauptverfasser:	Dhumale, Suhashini S., Waghela, Bhargav N., Pathak, Chandramani
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - pathology Advanced glycosylation end products Apoptosis Breast Neoplasms - metabolism Breast Neoplasms - pathology cancer Cell death Cell Line, Tumor Cell Proliferation Cell survival Dendritic cells HMGB1 HMGB1 protein HMGB1 Protein - metabolism Homeostasis Humans Ligands Lymphocytes T Macrophages Membrane Potential, Mitochondrial - drug effects Monocytes Necrosis Quercetin Quercetin - pharmacology RAGE Receptor for Advanced Glycation End Products - metabolism
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