Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome

In mammals, X-inactivation process is achieved by the cis -spreading of long noncoding Xist RNA over one of the female X chromosomes. The Xist binding accumulates histones H3 methylation and H4 hypoacetylation required for X inactivation that leads to proper dosage compensation of the X-linked genes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chromosoma 2015-06, Vol.124 (2), p.249-262
Hauptverfasser:	Kota, Satya Keerthi, Roy Chowdhury, Debabani, Rao, Lakshmi K., Padmalatha, Venkata, Singh, Lalji, Bhadra, Utpal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Biochemistry Biomedical and Life Sciences Cell Biology Cell Differentiation Chromatin - genetics Chromatin - metabolism Chromosomes, Human, X DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Developmental Biology DNA Damage Embryonic Stem Cells - metabolism Eukaryotic Microbiology Female Gene Silencing Genes, X-Linked HEK293 Cells HeLa Cells Histones - genetics Histones - metabolism Human Genetics Humans Jurkat Cells Life Sciences Male Mice Promoter Regions, Genetic Protein Binding Research Article Ribonuclease III - genetics Ribonuclease III - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transcription, Genetic Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism X Chromosome Inactivation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!