Therapeutic Development in Amyotrophic Lateral Sclerosis

Abstract Purpose Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults. It is almost invariably lethal within a few years after the onset of symptoms. No effective treatment is currently available beyond supportive care and riluzole, a putative glutamate release block...

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Veröffentlicht in:	Clinical therapeutics 2015-03, Vol.37 (3), p.668-680
Hauptverfasser:	Bucchia, Monica, MS, Ramirez, Agnese, MS, Parente, Valeria, PhD, Simone, Chiara, PhD, Nizzardo, Monica, PhD, Magri, Francesca, MD, Dametti, Sara, MS, Corti, Stefania, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - physiopathology Amyotrophic Lateral Sclerosis - therapy Clinical trials Disease Progression Drug dosages FDA approval Humans Internal Medicine Medical Education molecular targets Mortality motor neuron disease Neurons Oxidative stress Palliative care Parkinson's disease Riluzole - therapeutic use Rodents small molecules Studies Treatment Outcome
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