Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: An animal model for primary screening of antiatherosclerotic agents

We tried to develop an experimental model using mice for the primary screening of antiatherosclerotic agents. Male ICR strain mice were given a high-cholesterol diet supplemented with 10% linoleic acid for 14 weeks. Throughout the experimental period, weight gain of these mice was significantly inhi...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1993-11, Vol.30 (3), p.169-175
Hauptverfasser:	Yu, Yamaguchi, Satomi, Kitagawa, Noriko, Imaizumi, Masaru, Kunitomo, Motohatsu, Fujiwara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Aorta - drug effects Aorta - metabolism Aorta - pathology Aortic cholesterol deposition Arteriosclerosis - drug therapy Arteriosclerosis - metabolism Atherosclerosis Biological and medical sciences Cardiovascular system Cholesterol - metabolism Cholesterol, Dietary - metabolism Cholesterol, Dietary - pharmacology Desmosine - metabolism Disease Models, Animal Drug Evaluation, Preclinical Hypercholesterolemia Hypercholesterolemia - chemically induced Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism Linoleic Acid Linoleic Acids - metabolism Linoleic Acids - pharmacology Lipid peroxide Lipid Peroxides - blood Lipids - blood Male Medical sciences Mice Mice, Inbred ICR Pharmacology. Drug treatments Phosphatidylcholine-Sterol O-Acyltransferase - blood Phosphatidylcholine-Sterol O-Acyltransferase - drug effects Probucol - pharmacology Vascular wall
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