The dynemicin-DNA intercalation complex: a model based on DNA affinity cleavage and molecular dynamics simulation

The dynemicin-DNA intercalation complex: a model based on DNA affinity cleavage and molecular dynamics simulation

A model for the dynemicin-DNA complex has been constructed by using energy minimization (EM) and molecular dynamics (MD) techniques. The model is consistent with the available experimental data. This has allowed us to gain insights into (1) how dynemicin A is activated into a DNA cleaver, (2) its mo...

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Veröffentlicht in:Journal of the American Chemical Society 1991-06, Vol.113 (12), p.4395-4403
Hauptverfasser: Langley, D. R, Doyle, T. W, Beveridge, D. L
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Sprache:eng
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Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General and theoretical biochemistry
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container_end_page 4403
container_issue 12
container_start_page 4395
container_title Journal of the American Chemical Society
container_volume 113
creator Langley, D. R
Doyle, T. W
Beveridge, D. L
description A model for the dynemicin-DNA complex has been constructed by using energy minimization (EM) and molecular dynamics (MD) techniques. The model is consistent with the available experimental data. This has allowed us to gain insights into (1) how dynemicin A is activated into a DNA cleaver, (2) its mode of binding to DNA, (3) the absolute stereochemistry of dynemicin A, and (4) its DNA cleavage patterns and specificity.
doi_str_mv 10.1021/ja00012a004
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subjects Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General and theoretical biochemistry
title The dynemicin-DNA intercalation complex: a model based on DNA affinity cleavage and molecular dynamics simulation
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