A new dehydratase conferring innate resistance to thiacetazone and intra‐amoebal survival of Mycobacterium smegmatis

Summary Nontuberculous mycobacteria are innately resistant to most antibiotics, although the mechanisms responsible for their drug resistance remain poorly understood. They are particularly refractory to thiacetazone (TAC), a second‐line antitubercular drug. Herein, we identified MSMEG_6754 as essen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular microbiology 2015-06, Vol.96 (5), p.1085-1102
Hauptverfasser:	Carrère‐Kremer, Séverine, Blaise, Mickael, Singh, Vipul K., Alibaud, Laeticia, Tuaillon, Edouard, Halloum, Iman, Weerd, Robert, Guérardel, Yann, Drancourt, Michel, Takiff, Howard, Geurtsen, Jeroen, Kremer, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthamoeba castellanii - microbiology Animals Antibiotics Antitubercular Agents - pharmacology Bacteria Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biosynthesis Crystallography, X-Ray Dogs Drug resistance Drug Resistance, Multiple, Bacterial - genetics Gene Silencing Genetic Complementation Test Hydro-Lyases - chemistry Hydro-Lyases - genetics Hydro-Lyases - metabolism Microbial Viability - drug effects Molecular Conformation Mycobacterium smegmatis - drug effects Mycobacterium smegmatis - enzymology Mycobacterium smegmatis - genetics Mycobacterium smegmatis - physiology Mycobacterium tuberculosis - genetics Sequence Alignment Sequence Deletion Thioacetazone - pharmacology Tuberculosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!