Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure
Animal studies suggest that receptor for advanced glycation end products (RAGE)–dependent mechanisms contribute to acetaminophen‐induced liver damage. We examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) or RAGE ligands, including extracellular newly...
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| Veröffentlicht in: | Liver transplantation 2015-06, Vol.21 (6), p.847-854 |
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| creator | Basta, Giuseppina Del Turco, Serena Navarra, Teresa Lee, William M. |
| description | Animal studies suggest that receptor for advanced glycation end products (RAGE)–dependent mechanisms contribute to acetaminophen‐induced liver damage. We examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) or RAGE ligands, including extracellular newly identified receptor for advanced glycation end products binding protein (EN‐RAGE), high‐mobility group box 1 (HMGB1), and Nε‐(Carboxymethyl)lysine adducts (CML), could aid in prognostication after an acetaminophen overdose. Sixty well‐characterized acetaminophen‐related acute liver failure (ALF) patients (30 spontaneous survivors and 30 patients who underwent transplantation and/or died) who were enrolled in the National Institutes of Health–sponsored Acute Liver Failure Study Group, were matched by age, met standard criteria for encephalopathy, and had an international normalized ratio > 1.5 were retrospectively studied. HMGB1, EN‐RAGE, CML, and sRAGE were detected by enzyme‐linked immunosorbent assay methods in sera from ALF patients and 30 healthy controls. Levels of sRAGE, EN‐RAGE, and HMGB1 (but not CML) were significantly greater (P |
| doi_str_mv | 10.1002/lt.24129 |
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We examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) or RAGE ligands, including extracellular newly identified receptor for advanced glycation end products binding protein (EN‐RAGE), high‐mobility group box 1 (HMGB1), and Nε‐(Carboxymethyl)lysine adducts (CML), could aid in prognostication after an acetaminophen overdose. Sixty well‐characterized acetaminophen‐related acute liver failure (ALF) patients (30 spontaneous survivors and 30 patients who underwent transplantation and/or died) who were enrolled in the National Institutes of Health–sponsored Acute Liver Failure Study Group, were matched by age, met standard criteria for encephalopathy, and had an international normalized ratio > 1.5 were retrospectively studied. HMGB1, EN‐RAGE, CML, and sRAGE were detected by enzyme‐linked immunosorbent assay methods in sera from ALF patients and 30 healthy controls. Levels of sRAGE, EN‐RAGE, and HMGB1 (but not CML) were significantly greater (P < 0.001) in ALF patients versus normal controls. The levels of sRAGE, HMGB1, and EN‐RAGE were significantly higher (P = 0.03, P < 0.01, and P = 0.03) in patients with a systemic inflammatory response syndrome (SIRS) score > 2 versus patients with a SIRS score ≤ 2. Nevertheless, only sRAGE levels were significantly higher in patients who underwent transplantation and/or died versus spontaneous survivors (P < 0.001), and they were positively associated with conventional markers of liver disease severity. Multivariate logistic regression identified an encephalopathy grade > 2 as an independent predictor of an adverse outcome on admission (odds ratio, 13; 95% confidence interval, 2.3‐73; P < 0.001). The RAGE‐ligand axis may interfere with liver regeneration and should be a promising objective for further research. Liver Transpl 21:847‐854, 2015. © 2015 AASLD.</description><identifier>ISSN: 1527-6465</identifier><identifier>EISSN: 1527-6473</identifier><identifier>DOI: 10.1002/lt.24129</identifier><identifier>PMID: 25825217</identifier><identifier>CODEN: LITRFO</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc</publisher><subject>Acetaminophen - adverse effects ; Adult ; Analgesics ; Biomarkers - blood ; Case-Control Studies ; Confidence intervals ; Deaths ; Female ; Glycation End Products, Advanced - blood ; HMGB1 Protein - blood ; Humans ; Ligands ; Liver ; Liver Failure, Acute - blood ; Liver Failure, Acute - chemically induced ; Lysine - analogs & derivatives ; Lysine - blood ; Male ; Middle Aged ; Prospective Studies ; Receptor for Advanced Glycation End Products - blood ; S100A12 Protein - blood ; Young Adult</subject><ispartof>Liver transplantation, 2015-06, Vol.21 (6), p.847-854</ispartof><rights>2015 American Association for the Study of Liver Diseases</rights><rights>2015 American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3839-e5420f5086c9a47029b5dc1e318675609c88e6d35c49ed5670890455a5e5db083</citedby><cites>FETCH-LOGICAL-c3839-e5420f5086c9a47029b5dc1e318675609c88e6d35c49ed5670890455a5e5db083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flt.24129$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flt.24129$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25825217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basta, Giuseppina</creatorcontrib><creatorcontrib>Del Turco, Serena</creatorcontrib><creatorcontrib>Navarra, Teresa</creatorcontrib><creatorcontrib>Lee, William M.</creatorcontrib><creatorcontrib>Acute Liver Failure Study Group</creatorcontrib><title>Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure</title><title>Liver transplantation</title><addtitle>Liver Transpl</addtitle><description>Animal studies suggest that receptor for advanced glycation end products (RAGE)–dependent mechanisms contribute to acetaminophen‐induced liver damage. We examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) or RAGE ligands, including extracellular newly identified receptor for advanced glycation end products binding protein (EN‐RAGE), high‐mobility group box 1 (HMGB1), and Nε‐(Carboxymethyl)lysine adducts (CML), could aid in prognostication after an acetaminophen overdose. Sixty well‐characterized acetaminophen‐related acute liver failure (ALF) patients (30 spontaneous survivors and 30 patients who underwent transplantation and/or died) who were enrolled in the National Institutes of Health–sponsored Acute Liver Failure Study Group, were matched by age, met standard criteria for encephalopathy, and had an international normalized ratio > 1.5 were retrospectively studied. HMGB1, EN‐RAGE, CML, and sRAGE were detected by enzyme‐linked immunosorbent assay methods in sera from ALF patients and 30 healthy controls. Levels of sRAGE, EN‐RAGE, and HMGB1 (but not CML) were significantly greater (P < 0.001) in ALF patients versus normal controls. The levels of sRAGE, HMGB1, and EN‐RAGE were significantly higher (P = 0.03, P < 0.01, and P = 0.03) in patients with a systemic inflammatory response syndrome (SIRS) score > 2 versus patients with a SIRS score ≤ 2. Nevertheless, only sRAGE levels were significantly higher in patients who underwent transplantation and/or died versus spontaneous survivors (P < 0.001), and they were positively associated with conventional markers of liver disease severity. Multivariate logistic regression identified an encephalopathy grade > 2 as an independent predictor of an adverse outcome on admission (odds ratio, 13; 95% confidence interval, 2.3‐73; P < 0.001). The RAGE‐ligand axis may interfere with liver regeneration and should be a promising objective for further research. Liver Transpl 21:847‐854, 2015. © 2015 AASLD.</description><subject>Acetaminophen - adverse effects</subject><subject>Adult</subject><subject>Analgesics</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Deaths</subject><subject>Female</subject><subject>Glycation End Products, Advanced - blood</subject><subject>HMGB1 Protein - blood</subject><subject>Humans</subject><subject>Ligands</subject><subject>Liver</subject><subject>Liver Failure, Acute - blood</subject><subject>Liver Failure, Acute - chemically induced</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Receptor for Advanced Glycation End Products - blood</subject><subject>S100A12 Protein - blood</subject><subject>Young Adult</subject><issn>1527-6465</issn><issn>1527-6473</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU1rGzEQhkVoqF2nkF9QBL3ksomkXWmlYzFNGjDkkpwXWZp1ZORdVx8O_lX5i1XsfEChhx7EzIhnHgZehM4puaSEsCufLllDmTpBU8pZW4mmrT-994JP0JcY14RQyhX5jCaMS8YZbafoee6CyV4nN6ywhx34iMcex9HnpQccwMA2jQH35Wm704MBi1d-b8rGOGAYLN6G0WaTItZl8G5VysGRHv9z3w14W75hKP2TS49Ym5ygKHdQBNr5HOAMnfbaR_j6Wmfo4frn_fxXtbi7uZ3_WFSmlrWqgDeM9JxIYZRuWsLUkltDoaZStFwQZaQEYWtuGgWWi5ZIRRrONQdul0TWM3Rx9JbrfmeIqdu4aMB7PcCYY0eFrFuuiqmg3_9C12MOQ7nuQBFFhGo_hCaMMQbou21wGx32HSXdS4idT90hxIJ-exXm5QbsO_iWWgGqI_DkPOz_KeoW90fhH8B2p3s</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Basta, Giuseppina</creator><creator>Del Turco, Serena</creator><creator>Navarra, Teresa</creator><creator>Lee, William M.</creator><general>Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure</title><author>Basta, Giuseppina ; Del Turco, Serena ; Navarra, Teresa ; Lee, William M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3839-e5420f5086c9a47029b5dc1e318675609c88e6d35c49ed5670890455a5e5db083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acetaminophen - adverse effects</topic><topic>Adult</topic><topic>Analgesics</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Deaths</topic><topic>Female</topic><topic>Glycation End Products, Advanced - blood</topic><topic>HMGB1 Protein - blood</topic><topic>Humans</topic><topic>Ligands</topic><topic>Liver</topic><topic>Liver Failure, Acute - blood</topic><topic>Liver Failure, Acute - chemically induced</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Receptor for Advanced Glycation End Products - blood</topic><topic>S100A12 Protein - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basta, Giuseppina</creatorcontrib><creatorcontrib>Del Turco, Serena</creatorcontrib><creatorcontrib>Navarra, Teresa</creatorcontrib><creatorcontrib>Lee, William M.</creatorcontrib><creatorcontrib>Acute Liver Failure Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Liver transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basta, Giuseppina</au><au>Del Turco, Serena</au><au>Navarra, Teresa</au><au>Lee, William M.</au><aucorp>Acute Liver Failure Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure</atitle><jtitle>Liver transplantation</jtitle><addtitle>Liver Transpl</addtitle><date>2015-06</date><risdate>2015</risdate><volume>21</volume><issue>6</issue><spage>847</spage><epage>854</epage><pages>847-854</pages><issn>1527-6465</issn><eissn>1527-6473</eissn><coden>LITRFO</coden><abstract>Animal studies suggest that receptor for advanced glycation end products (RAGE)–dependent mechanisms contribute to acetaminophen‐induced liver damage. We examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) or RAGE ligands, including extracellular newly identified receptor for advanced glycation end products binding protein (EN‐RAGE), high‐mobility group box 1 (HMGB1), and Nε‐(Carboxymethyl)lysine adducts (CML), could aid in prognostication after an acetaminophen overdose. Sixty well‐characterized acetaminophen‐related acute liver failure (ALF) patients (30 spontaneous survivors and 30 patients who underwent transplantation and/or died) who were enrolled in the National Institutes of Health–sponsored Acute Liver Failure Study Group, were matched by age, met standard criteria for encephalopathy, and had an international normalized ratio > 1.5 were retrospectively studied. HMGB1, EN‐RAGE, CML, and sRAGE were detected by enzyme‐linked immunosorbent assay methods in sera from ALF patients and 30 healthy controls. Levels of sRAGE, EN‐RAGE, and HMGB1 (but not CML) were significantly greater (P < 0.001) in ALF patients versus normal controls. The levels of sRAGE, HMGB1, and EN‐RAGE were significantly higher (P = 0.03, P < 0.01, and P = 0.03) in patients with a systemic inflammatory response syndrome (SIRS) score > 2 versus patients with a SIRS score ≤ 2. Nevertheless, only sRAGE levels were significantly higher in patients who underwent transplantation and/or died versus spontaneous survivors (P < 0.001), and they were positively associated with conventional markers of liver disease severity. Multivariate logistic regression identified an encephalopathy grade > 2 as an independent predictor of an adverse outcome on admission (odds ratio, 13; 95% confidence interval, 2.3‐73; P < 0.001). The RAGE‐ligand axis may interfere with liver regeneration and should be a promising objective for further research. Liver Transpl 21:847‐854, 2015. © 2015 AASLD.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc</pub><pmid>25825217</pmid><doi>10.1002/lt.24129</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Liver transplantation, 2015-06, Vol.21 (6), p.847-854 |
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| subjects | Acetaminophen - adverse effects Adult Analgesics Biomarkers - blood Case-Control Studies Confidence intervals Deaths Female Glycation End Products, Advanced - blood HMGB1 Protein - blood Humans Ligands Liver Liver Failure, Acute - blood Liver Failure, Acute - chemically induced Lysine - analogs & derivatives Lysine - blood Male Middle Aged Prospective Studies Receptor for Advanced Glycation End Products - blood S100A12 Protein - blood Young Adult |
| title | Circulating levels of soluble receptor for advanced glycation end products and ligands of the receptor for advanced glycation end products in patients with acute liver failure |
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