Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome
SUMMARY Objectives To observe and compare the clinical curative effect of the plasma exchange (PE) and intravenous immunoglobulin (IVIg) for Guillian–Barre Syndrome (GBS). Methods Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre‐treatm...
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| Veröffentlicht in: | Transfusion medicine (Oxford, England) England), 2015-04, Vol.25 (2), p.79-84 |
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| creator | Ye, Y. Li, S.-L. Li, Y.-J. |
| description | SUMMARY
Objectives
To observe and compare the clinical curative effect of the plasma exchange (PE) and intravenous immunoglobulin (IVIg) for Guillian–Barre Syndrome (GBS).
Methods
Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre‐treatment and at 1 week/2 weeks after completion of treatment; the blood immunoglobulin, complement, fibrinogen (Fib) and monocyte percentage (MON%) were detected simultaneously.
Results
After PE treatment, nerve function defect appeared to improve better than the IVIg group and clinical effect was better than the IVIg group. Treatment effective rates of the two groups after 2 weeks, respectively, are 96 and 79%. PE and IVIg can significantly reduce the GBS patients' blood immunoglobulin IgG, IgA, IgM, C3 and C4, but these were significantly lower in the PE group than in the IVIg group. Fib and MON% were significantly lower in the PE group than in the IVIg group.
Conclusion
Both PE and IVIg have a high response as therapy and are reasonable therapeutic options for GBS. However, PE treatment has a more significantly curative effect, as it can effectively improve symptoms and be helpful in the early rehabilitation of patients. |
| doi_str_mv | 10.1111/tme.12169 |
| format | Article |
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Objectives
To observe and compare the clinical curative effect of the plasma exchange (PE) and intravenous immunoglobulin (IVIg) for Guillian–Barre Syndrome (GBS).
Methods
Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre‐treatment and at 1 week/2 weeks after completion of treatment; the blood immunoglobulin, complement, fibrinogen (Fib) and monocyte percentage (MON%) were detected simultaneously.
Results
After PE treatment, nerve function defect appeared to improve better than the IVIg group and clinical effect was better than the IVIg group. Treatment effective rates of the two groups after 2 weeks, respectively, are 96 and 79%. PE and IVIg can significantly reduce the GBS patients' blood immunoglobulin IgG, IgA, IgM, C3 and C4, but these were significantly lower in the PE group than in the IVIg group. Fib and MON% were significantly lower in the PE group than in the IVIg group.
Conclusion
Both PE and IVIg have a high response as therapy and are reasonable therapeutic options for GBS. However, PE treatment has a more significantly curative effect, as it can effectively improve symptoms and be helpful in the early rehabilitation of patients.</description><identifier>ISSN: 0958-7578</identifier><identifier>EISSN: 1365-3148</identifier><identifier>DOI: 10.1111/tme.12169</identifier><identifier>PMID: 25515056</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Complement System Proteins - analysis ; Female ; Fibrinogen - analysis ; Follow-Up Studies ; Guillain-Barre Syndrome - therapy ; Guillian-Barre syndrome ; Humans ; Immunoglobulins - analysis ; Immunoglobulins, Intravenous - therapeutic use ; Immunosuppression - methods ; intravenous immuno-globulin ; Leukocyte Count ; Male ; Monocytes ; Neurologic Examination ; Plasma Exchange ; Young Adult</subject><ispartof>Transfusion medicine (Oxford, England), 2015-04, Vol.25 (2), p.79-84</ispartof><rights>2014 British Blood Transfusion Society</rights><rights>2014 British Blood Transfusion Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4339-12be722d7d900c606746b76250b19a18015ca4f182ce625b4f5c7ab5344cc0503</citedby><cites>FETCH-LOGICAL-c4339-12be722d7d900c606746b76250b19a18015ca4f182ce625b4f5c7ab5344cc0503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftme.12169$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftme.12169$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25515056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ye, Y.</creatorcontrib><creatorcontrib>Li, S.-L.</creatorcontrib><creatorcontrib>Li, Y.-J.</creatorcontrib><title>Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome</title><title>Transfusion medicine (Oxford, England)</title><addtitle>Transfusion Med</addtitle><description>SUMMARY
Objectives
To observe and compare the clinical curative effect of the plasma exchange (PE) and intravenous immunoglobulin (IVIg) for Guillian–Barre Syndrome (GBS).
Methods
Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre‐treatment and at 1 week/2 weeks after completion of treatment; the blood immunoglobulin, complement, fibrinogen (Fib) and monocyte percentage (MON%) were detected simultaneously.
Results
After PE treatment, nerve function defect appeared to improve better than the IVIg group and clinical effect was better than the IVIg group. Treatment effective rates of the two groups after 2 weeks, respectively, are 96 and 79%. PE and IVIg can significantly reduce the GBS patients' blood immunoglobulin IgG, IgA, IgM, C3 and C4, but these were significantly lower in the PE group than in the IVIg group. Fib and MON% were significantly lower in the PE group than in the IVIg group.
Conclusion
Both PE and IVIg have a high response as therapy and are reasonable therapeutic options for GBS. However, PE treatment has a more significantly curative effect, as it can effectively improve symptoms and be helpful in the early rehabilitation of patients.</description><subject>Adult</subject><subject>Complement System Proteins - analysis</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Follow-Up Studies</subject><subject>Guillain-Barre Syndrome - therapy</subject><subject>Guillian-Barre syndrome</subject><subject>Humans</subject><subject>Immunoglobulins - analysis</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunosuppression - methods</subject><subject>intravenous immuno-globulin</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Monocytes</subject><subject>Neurologic Examination</subject><subject>Plasma Exchange</subject><subject>Young Adult</subject><issn>0958-7578</issn><issn>1365-3148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1TAQhS1E1V5KF7wA8pIu0vontpMlROWCKGVT1KXlOJPWENvBTqD37THctruORhpp9J2jo4PQG0rOaJnzxcMZZVS2L9CGcikqTuvmJdqQVjSVEqo5Qq9y_kEI5axlh-iICUEFEXKDQhf9bJLLMeCyyx0kM8O6OIthHMEuOI54nkz2BsO9vTPhFrAJA3ZhSeY3hLhm7LxfQ7ydYr9OLuAxJrxd3TQ5E6oPJiXAeReGFD28RgejmTKcPNxj9P3jxXX3qbr8tv3cvb-sbM15W1HWg2JsUENLiJVEqlr2SjJBetoa2hAqrKlH2jAL5dvXo7DK9ILXtbVEEH6M3u195xR_rZAX7V22ME0mQEmsqWy4ElLJtqCne9SmmHOCUc_JeZN2mhL9r15d6tX_6y3s2wfbtfcwPJGPfRbgfA_8cRPsnnfS118vHi2rvcLlBe6fFCb91FKVjPrmaqu7L4LLjt3oK_4XG3iUQQ</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Ye, Y.</creator><creator>Li, S.-L.</creator><creator>Li, Y.-J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome</title><author>Ye, Y. ; Li, S.-L. ; Li, Y.-J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4339-12be722d7d900c606746b76250b19a18015ca4f182ce625b4f5c7ab5344cc0503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Complement System Proteins - analysis</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Follow-Up Studies</topic><topic>Guillain-Barre Syndrome - therapy</topic><topic>Guillian-Barre syndrome</topic><topic>Humans</topic><topic>Immunoglobulins - analysis</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Immunosuppression - methods</topic><topic>intravenous immuno-globulin</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Monocytes</topic><topic>Neurologic Examination</topic><topic>Plasma Exchange</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ye, Y.</creatorcontrib><creatorcontrib>Li, S.-L.</creatorcontrib><creatorcontrib>Li, Y.-J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion medicine (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ye, Y.</au><au>Li, S.-L.</au><au>Li, Y.-J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome</atitle><jtitle>Transfusion medicine (Oxford, England)</jtitle><addtitle>Transfusion Med</addtitle><date>2015-04</date><risdate>2015</risdate><volume>25</volume><issue>2</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0958-7578</issn><eissn>1365-3148</eissn><abstract>SUMMARY
Objectives
To observe and compare the clinical curative effect of the plasma exchange (PE) and intravenous immunoglobulin (IVIg) for Guillian–Barre Syndrome (GBS).
Methods
Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre‐treatment and at 1 week/2 weeks after completion of treatment; the blood immunoglobulin, complement, fibrinogen (Fib) and monocyte percentage (MON%) were detected simultaneously.
Results
After PE treatment, nerve function defect appeared to improve better than the IVIg group and clinical effect was better than the IVIg group. Treatment effective rates of the two groups after 2 weeks, respectively, are 96 and 79%. PE and IVIg can significantly reduce the GBS patients' blood immunoglobulin IgG, IgA, IgM, C3 and C4, but these were significantly lower in the PE group than in the IVIg group. Fib and MON% were significantly lower in the PE group than in the IVIg group.
Conclusion
Both PE and IVIg have a high response as therapy and are reasonable therapeutic options for GBS. However, PE treatment has a more significantly curative effect, as it can effectively improve symptoms and be helpful in the early rehabilitation of patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>25515056</pmid><doi>10.1111/tme.12169</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Complement System Proteins - analysis Female Fibrinogen - analysis Follow-Up Studies Guillain-Barre Syndrome - therapy Guillian-Barre syndrome Humans Immunoglobulins - analysis Immunoglobulins, Intravenous - therapeutic use Immunosuppression - methods intravenous immuno-globulin Leukocyte Count Male Monocytes Neurologic Examination Plasma Exchange Young Adult |
| title | Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome |
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