Structure-inhibition relationship of podophyllotoxin (PT) analogues towards UDP-glucuronosyltransferase (UGT) isoforms

UDP-glucuronosyltransferases (UGTs) are involved in the clearance of many important drugs and endogenous substances, and inhibition of UGTs' activity by herbal components might induce severe herb-drug interactions or metabolic disturbances of endogenous substances. The present study aims to det...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmazie 2015-04, Vol.70 (4), p.239-243
Hauptverfasser:	Qi, Jia-Qi, Cao, Yun-Feng, Sun, Xiao-Yu, Hong, Mo, Fang, Zhong-Ze, Meng, Da-Li, Sun, Dong-Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive - drug effects Camptothecin - analogs & derivatives Camptothecin - metabolism Drug Interactions Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Estradiol - metabolism Glucuronides - metabolism Glucuronosyltransferase - antagonists & inhibitors Humans Hymecromone - metabolism In Vitro Techniques Isoenzymes - antagonists & inhibitors Microsomes, Liver - drug effects Microsomes, Liver - enzymology Podophyllotoxin - chemistry Podophyllotoxin - pharmacology Structure-Activity Relationship Substrate Specificity Trifluoperazine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!