Predictors of health‐related quality of life of European food‐allergic patients

Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute...

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Veröffentlicht in:Allergy (Copenhagen) 2015-06, Vol.70 (6), p.616-624
Hauptverfasser: Saleh‐Langenberg, J., Goossens, N. J., Flokstra‐de Blok, B. M. J., Kollen, B. J., Meulen, G. N., Le, T. M., Knulst, A. C., Jedrzejczak‐Czechowicz, M., Kowalski, M. L., Rokicka, E., Starosta, P., Hoz Caballer, B., Vazquez‐Cortés, S., Cerecedo, I., Barreales, L., Asero, R., Clausen, M., DunnGalvin, A., Hourihane, J. O'. B., Purohit, A., Papadopoulos, N. G., Fernandéz‐Rivas, M., Frewer, L., Burney, P., Duiverman, E. J., Dubois, A. E. J.
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container_end_page 624
container_issue 6
container_start_page 616
container_title Allergy (Copenhagen)
container_volume 70
creator Saleh‐Langenberg, J.
Goossens, N. J.
Flokstra‐de Blok, B. M. J.
Kollen, B. J.
Meulen, G. N.
Le, T. M.
Knulst, A. C.
Jedrzejczak‐Czechowicz, M.
Kowalski, M. L.
Rokicka, E.
Starosta, P.
Hoz Caballer, B.
Vazquez‐Cortés, S.
Cerecedo, I.
Barreales, L.
Asero, R.
Clausen, M.
DunnGalvin, A.
Hourihane, J. O'. B.
Purohit, A.
Papadopoulos, N. G.
Fernandéz‐Rivas, M.
Frewer, L.
Burney, P.
Duiverman, E. J.
Dubois, A. E. J.
description Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food‐allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food‐allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food‐allergic patients (404 adults, 244 children) completed an age‐specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto‐injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy‐related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.
doi_str_mv 10.1111/all.12582
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J. ; Flokstra‐de Blok, B. M. J. ; Kollen, B. J. ; Meulen, G. N. ; Le, T. M. ; Knulst, A. C. ; Jedrzejczak‐Czechowicz, M. ; Kowalski, M. L. ; Rokicka, E. ; Starosta, P. ; Hoz Caballer, B. ; Vazquez‐Cortés, S. ; Cerecedo, I. ; Barreales, L. ; Asero, R. ; Clausen, M. ; DunnGalvin, A. ; Hourihane, J. O'. B. ; Purohit, A. ; Papadopoulos, N. G. ; Fernandéz‐Rivas, M. ; Frewer, L. ; Burney, P. ; Duiverman, E. J. ; Dubois, A. E. J.</creator><creatorcontrib>Saleh‐Langenberg, J. ; Goossens, N. J. ; Flokstra‐de Blok, B. M. J. ; Kollen, B. J. ; Meulen, G. N. ; Le, T. M. ; Knulst, A. C. ; Jedrzejczak‐Czechowicz, M. ; Kowalski, M. L. ; Rokicka, E. ; Starosta, P. ; Hoz Caballer, B. ; Vazquez‐Cortés, S. ; Cerecedo, I. ; Barreales, L. ; Asero, R. ; Clausen, M. ; DunnGalvin, A. ; Hourihane, J. O'. B. ; Purohit, A. ; Papadopoulos, N. G. ; Fernandéz‐Rivas, M. ; Frewer, L. ; Burney, P. ; Duiverman, E. J. ; Dubois, A. E. J.</creatorcontrib><description>Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food‐allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food‐allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food‐allergic patients (404 adults, 244 children) completed an age‐specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto‐injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy‐related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.12582</identifier><identifier>PMID: 25627424</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Allergies ; Anaphylaxis - drug therapy ; Anaphylaxis - etiology ; Child ; Epinephrine - therapeutic use ; epinephrine auto‐injector ; Europe ; Female ; Food ; Food allergies ; food allergy ; food allergy quality‐of‐life questionnaire ; Food Hypersensitivity - complications ; Food Hypersensitivity - drug therapy ; Food Hypersensitivity - psychology ; France ; Greece ; Health Status ; health‐related quality of life ; Humans ; Iceland ; Ireland ; Italy ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Netherlands ; Poland ; Quality of Life ; Risk Factors ; Severity of Illness Index ; Spain ; Surveys and Questionnaires ; Sympathomimetics - therapeutic use ; Young Adult</subject><ispartof>Allergy (Copenhagen), 2015-06, Vol.70 (6), p.616-624</ispartof><rights>2015 John Wiley &amp; Sons A/S. 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J.</creatorcontrib><creatorcontrib>Flokstra‐de Blok, B. M. J.</creatorcontrib><creatorcontrib>Kollen, B. J.</creatorcontrib><creatorcontrib>Meulen, G. N.</creatorcontrib><creatorcontrib>Le, T. M.</creatorcontrib><creatorcontrib>Knulst, A. C.</creatorcontrib><creatorcontrib>Jedrzejczak‐Czechowicz, M.</creatorcontrib><creatorcontrib>Kowalski, M. L.</creatorcontrib><creatorcontrib>Rokicka, E.</creatorcontrib><creatorcontrib>Starosta, P.</creatorcontrib><creatorcontrib>Hoz Caballer, B.</creatorcontrib><creatorcontrib>Vazquez‐Cortés, S.</creatorcontrib><creatorcontrib>Cerecedo, I.</creatorcontrib><creatorcontrib>Barreales, L.</creatorcontrib><creatorcontrib>Asero, R.</creatorcontrib><creatorcontrib>Clausen, M.</creatorcontrib><creatorcontrib>DunnGalvin, A.</creatorcontrib><creatorcontrib>Hourihane, J. O'. B.</creatorcontrib><creatorcontrib>Purohit, A.</creatorcontrib><creatorcontrib>Papadopoulos, N. G.</creatorcontrib><creatorcontrib>Fernandéz‐Rivas, M.</creatorcontrib><creatorcontrib>Frewer, L.</creatorcontrib><creatorcontrib>Burney, P.</creatorcontrib><creatorcontrib>Duiverman, E. J.</creatorcontrib><creatorcontrib>Dubois, A. E. J.</creatorcontrib><title>Predictors of health‐related quality of life of European food‐allergic patients</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food‐allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food‐allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food‐allergic patients (404 adults, 244 children) completed an age‐specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto‐injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy‐related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. 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G.</creatorcontrib><creatorcontrib>Fernandéz‐Rivas, M.</creatorcontrib><creatorcontrib>Frewer, L.</creatorcontrib><creatorcontrib>Burney, P.</creatorcontrib><creatorcontrib>Duiverman, E. J.</creatorcontrib><creatorcontrib>Dubois, A. E. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saleh‐Langenberg, J.</au><au>Goossens, N. J.</au><au>Flokstra‐de Blok, B. M. J.</au><au>Kollen, B. J.</au><au>Meulen, G. N.</au><au>Le, T. M.</au><au>Knulst, A. C.</au><au>Jedrzejczak‐Czechowicz, M.</au><au>Kowalski, M. L.</au><au>Rokicka, E.</au><au>Starosta, P.</au><au>Hoz Caballer, B.</au><au>Vazquez‐Cortés, S.</au><au>Cerecedo, I.</au><au>Barreales, L.</au><au>Asero, R.</au><au>Clausen, M.</au><au>DunnGalvin, A.</au><au>Hourihane, J. O'. B.</au><au>Purohit, A.</au><au>Papadopoulos, N. G.</au><au>Fernandéz‐Rivas, M.</au><au>Frewer, L.</au><au>Burney, P.</au><au>Duiverman, E. J.</au><au>Dubois, A. E. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of health‐related quality of life of European food‐allergic patients</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2015-06</date><risdate>2015</risdate><volume>70</volume><issue>6</issue><spage>616</spage><epage>624</epage><pages>616-624</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food‐allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food‐allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. Methods A total of 648 European food‐allergic patients (404 adults, 244 children) completed an age‐specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. Results For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto‐injector (EAI) contributed to impairment of HRQL. Conclusions In this study, food allergy‐related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>25627424</pmid><doi>10.1111/all.12582</doi><tpages>9</tpages></addata></record>
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source Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals
subjects Adolescent
Adult
Allergies
Anaphylaxis - drug therapy
Anaphylaxis - etiology
Child
Epinephrine - therapeutic use
epinephrine auto‐injector
Europe
Female
Food
Food allergies
food allergy
food allergy quality‐of‐life questionnaire
Food Hypersensitivity - complications
Food Hypersensitivity - drug therapy
Food Hypersensitivity - psychology
France
Greece
Health Status
health‐related quality of life
Humans
Iceland
Ireland
Italy
Linear Models
Male
Middle Aged
Multivariate Analysis
Netherlands
Poland
Quality of Life
Risk Factors
Severity of Illness Index
Spain
Surveys and Questionnaires
Sympathomimetics - therapeutic use
Young Adult
title Predictors of health‐related quality of life of European food‐allergic patients
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