A Modular Approach to the Total Synthesis of Tunicamycins

The tunicamycins constitute a delicate mimic of the bisubstrate intermediates of N‐acetyl‐D‐hexosamine‐1‐phosphate translocases and thus inhibit bacterial cell‐wall synthesis and the N glycosylation of eukaryotic proteins. An efficient approach to the synthesis of this unique type of nucleoside anti...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-05, Vol.54 (22), p.6618-6621
Hauptverfasser:	Li, Jiakun, Yu, Biao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Aldehydes Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Catalysis Glycosylation gold Gold - chemistry nucleosides Stereoisomerism total synthesis tunicamycin Tunicamycin - chemical synthesis Tunicamycin - chemistry
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