The antiinflammatory activity of topically applied novel calcium-channel antagonists

The antiinflammatory activities of two novel calcium-channel antagonists, AGN 190742 and AGN 190744, were evaluated in murine models of cutaneous inflammation. These 2(5H)-furanone ring compounds block both depolarization-dependent Ca2+ entry and receptor-mediated responses in GH3 cells. Topical app...

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Veröffentlicht in:	Inflammation 1995-04, Vol.19 (2), p.261-275
Hauptverfasser:	De Vries, G W, McLaughlin, A, Wenzel, M B, Perez, J, Harcourt, D, Lee, G, Garst, M, Wheeler, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arachidonic Acid - secretion Arachidonic Acid - toxicity Calcium - metabolism Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - pharmacology Chemotaxis, Leukocyte - drug effects Clobetasol - analogs & derivatives Clobetasol - pharmacology Ear, External Epidermis - drug effects Epidermis - pathology Female Humans Hyperplasia Inflammation Mice Neutrophils - drug effects Neutrophils - enzymology Neutrophils - secretion Nifedipine - pharmacology Peroxidase - analysis Phosphatidylinositol Diacylglycerol-Lyase Phosphodiesterase Inhibitors - pharmacology Phospholipases A - antagonists & inhibitors Phosphoric Diester Hydrolases - metabolism Pituitary Neoplasms - pathology Potassium Chloride - antagonists & inhibitors Pyrazoles - pharmacology Terpenes - pharmacology Tetradecanoylphorbol Acetate - toxicity Thyrotropin-Releasing Hormone - antagonists & inhibitors Tumor Cells, Cultured - drug effects
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