Structure-Based Prediction of G‑Protein-Coupled Receptor Ligand Function: A β‑Adrenoceptor Case Study

The spectacular advances in G-protein-coupled receptor (GPCR) structure determination have opened up new possibilities for structure-based GPCR ligand discovery. The structure-based prediction of whether a ligand stimulates (full/partial agonist), blocks (antagonist), or reduces (inverse agonist) GP...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of chemical information and modeling 2015-05, Vol.55 (5), p.1045-1061
Hauptverfasser:	Kooistra, Albert J, Leurs, Rob, de Esch, Iwan J. P, de Graaf, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Agonists - metabolism Adrenergic beta-1 Receptor Agonists - pharmacology Adrenergic beta-1 Receptor Antagonists - metabolism Adrenergic beta-1 Receptor Antagonists - pharmacology Adrenergic beta-2 Receptor Agonists - metabolism Adrenergic beta-2 Receptor Agonists - pharmacology Adrenergic beta-2 Receptor Antagonists - metabolism Adrenergic beta-2 Receptor Antagonists - pharmacology Animals Computational Biology - methods Crystallography, X-Ray Drug Evaluation, Preclinical Humans Ligands Molecular Docking Simulation Protein Conformation Receptors, Adrenergic, beta-1 - chemistry Receptors, Adrenergic, beta-1 - metabolism Receptors, Adrenergic, beta-2 - chemistry Receptors, Adrenergic, beta-2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!