Massively Parallel DNA Sequencing Successfully Identified Seven Families With Deafness-Associated MYO6 Mutations: The Mutational Spectrum and Clinical Characteristics

Objectives: To elucidate the involvement of MYO6 mutations, known to be responsible for DFNA22/DFNB37, in Japanese hearing loss patients through the use of genetic analysis. Methods: Genomic variations responsible for hearing loss were identified by massively parallel DNA sequencing (MPS) of 63 targ...

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Veröffentlicht in:	Annals of otology, rhinology & laryngology rhinology & laryngology, 2015-05, Vol.124 (1_suppl), p.148S-157S
Hauptverfasser:	Miyagawa, Maiko, Nishio, Shin-ya, Kumakawa, Kozo, Usami, Shin-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Asian Continental Ancestry Group - genetics Codon, Nonsense Deafness - genetics DNA Mutational Analysis - methods Female Hearing Loss - genetics Humans Male Mutation, Missense - physiology Myosin Heavy Chains - genetics Pedigree
Online-Zugang:	Volltext
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