Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson's disease

Parkinson's disease is characterized by an increased excitatory amino acid transmission in the internal segment of the globus pallidus and the substantia nigra pars reticulata. The effects of the kappa receptor agonist enadoline (CI-977) on glutamate transmission were investigated in vitro. Ena...

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Veröffentlicht in:	Brain research 1995-06, Vol.683 (1), p.102-108
Hauptverfasser:	Maneuf, Yannick P., Mitchell, Ian J., Crossman, Alan R., Woodruff, Geoffrey N., Brotchie, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Anti-Arrhythmia Agents - pharmacology Basal Ganglia - drug effects Basal Ganglia - metabolism Basal Ganglia - physiopathology Benzofurans - pharmacology Biological and medical sciences Callithrix Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Glutamate transmission Glutamic Acid - metabolism Glutamic Acid - physiology In Vitro Techniques Kappa opioid Male Medical sciences Motor Activity - drug effects Naltrexone - analogs & derivatives Naltrexone - pharmacology Neurology Output regions of the basal ganglia Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - physiopathology Parkinson's disease primates Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - physiology Reserpine - pharmacology Rodentia Synaptic Transmission - drug effects Synaptic Transmission - physiology
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