NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polić and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ. An important cause of obesity-induced insulin resistance is chr...

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Veröffentlicht in:	Nature immunology 2015-04, Vol.16 (4), p.376-385
Hauptverfasser:	Wensveen, Felix M, Jelenčić, Vedrana, Valentić, Sonja, Šestan, Marko, Wensveen, Tamara Turk, Theurich, Sebastian, Glasner, Ariella, Mendrila, Davor, Štimac, Davor, Wunderlich, F Thomas, Brüning, Jens C, Mandelboim, Ofer, Polić, Bojan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/95 14/1 14/35 38/77 631/250/1619/382 64/60 82/29 96/95 Accumulation Adipocytes - immunology Adipocytes - pathology Adipose tissue Adipose tissues Animals Antigens, Ly - genetics Antigens, Ly - immunology Biomedicine Cell Differentiation Development and progression Female Gene Expression Regulation Genetic aspects Humans Immunology Infectious Diseases Inflammation - genetics Inflammation - immunology Inflammation - pathology Insulin - immunology Insulin resistance Insulin Resistance - immunology Interferon-gamma - biosynthesis Interferon-gamma - immunology Intra-Abdominal Fat - immunology Intra-Abdominal Fat - pathology Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - pathology Macrophages - immunology Macrophages - pathology Male Mice Mice, Inbred C57BL Natural Cytotoxicity Triggering Receptor 1 - genetics Natural Cytotoxicity Triggering Receptor 1 - immunology Obesity Obesity - genetics Obesity - immunology Obesity - pathology Physiological aspects Risk factors Signal Transduction
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