The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

PLVAP is a blood vessel endothelium marker of uncertain function. Salmi and colleagues demonstrate that PLVAP is also expressed on lymphoid endothelial cells, where it regulates the entry of antigen and lymphocytes into the lymph nodes. In the lymphatic sinuses of draining lymph nodes, soluble lymph...

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Veröffentlicht in:	Nature immunology 2015-04, Vol.16 (4), p.386-396
Hauptverfasser:	Rantakari, Pia, Auvinen, Kaisa, Jäppinen, Norma, Kapraali, Maria, Valtonen, Joona, Karikoski, Marika, Gerke, Heidi, Iftakhar-E-Khuda, Imtiaz, Keuschnigg, Johannes, Umemoto, Eiji, Tohya, Kazuo, Miyasaka, Masayuki, Elima, Kati, Jalkanen, Sirpa, Salmi, Marko
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/19 14/28 14/34 14/35 631/250/1617/2069 64/110 Animals Antigens Antigens - immunology Antigens, CD - genetics Antigens, CD - metabolism Biomedicine Carrier Proteins - genetics Carrier Proteins - immunology Caveolin 1 - deficiency Caveolin 1 - genetics Caveolin 1 - immunology Endothelial Cells - cytology Endothelial Cells - immunology Endothelium Endothelium, Lymphatic - cytology Endothelium, Lymphatic - immunology Female Gene Expression Regulation Genetic aspects Immune response Immunology Infectious Diseases Lymph nodes Lymph Nodes - cytology Lymph Nodes - immunology Lymphatic Vessels - cytology Lymphatic Vessels - immunology Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Male Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Physiological aspects Signal Transduction Transendothelial and Transepithelial Migration - immunology
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