p85α is a microRNA target and affects chemosensitivity in pancreatic cancer

Abstract Background We previously identified a correlation between increased expression of the phosphoinositide 3-kinase (PI3K) regulatory subunit p85α and improved survival in human pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to investigate the impact of changes in p85α e...

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Veröffentlicht in:	The Journal of surgical research 2015-06, Vol.196 (2), p.285-293
Hauptverfasser:	Toste, Paul A., MD, Li, Luyi, MS, Kadera, Brian E., MD, Nguyen, Andrew H., MD, Tran, Linh M., PhD, Wu, Nanping, PhD, Madnick, David L., BS, Patel, Sanjeet G., MD, Dawson, David W., MD, PhD, Donahue, Timothy R., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - therapeutic use Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Cell Line, Tumor Chemoresistance Class Ia Phosphatidylinositol 3-Kinase - metabolism Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use HEK293 Cells Humans MicroRNAs - metabolism miR-21 p85α Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Phosphatidylinositol 3-Kinases - metabolism PIK3R1 Proto-Oncogene Proteins c-akt - metabolism Surgery
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