Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells

We have recently shown that targeted expression of myelin oligodendrocyte glycoprotein (MOG) to dendritic cells with self-inactivating-lentivirus vectors induces antigen-specific tolerance in naive antigen-specific CD4+ T cells and protects mice from experimental autoimmune encephalomyelitis (EAE)....

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Veröffentlicht in:	Gene therapy 2015-05, Vol.22 (5), p.382-390
Hauptverfasser:	de Andrade Pereira, B, Ackermann, M, Chaudhary, S, Vogel, R, Vogt, B, Dresch, C, Fraefel, C
Format:	Artikel
Sprache:	eng
Schlagworte:	42 42/100 631/250/38 631/532/1542 Adoptive Transfer Analysis Anergy Animals Antigens Autoantigens B cells Biomedical and Life Sciences Biomedicine Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Biology Cells, Cultured Cellular biology Cytokines Cytokines - genetics Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Diagnosis Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Experimental allergic encephalomyelitis Expression vectors Female Gene Expression Gene Therapy Genetic aspects Genetic transcription Health aspects Human Genetics Immune system Immunological tolerance Immunoregulation Inflammation Lymphocyte Activation Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Multiple sclerosis Myelin Myelin proteins Myelin-Oligodendrocyte Glycoprotein - immunology Nanotechnology Oligodendrocyte-myelin glycoprotein original-article Peptide Fragments - immunology T cells Transcription Transcription (Genetics) Up-Regulation
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