miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2

MicroRNAs (miRNAs) regulate many key cancer-relevant pathways and may themselves possess oncogenic or tumor-suppressor functions. Consequently, miRNA dysregulation has been shown to be a prominent feature in many human cancers. The p53 tumor suppressor acts as a negative regulator of cell proliferat...

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Veröffentlicht in:	Oncogene 2015-04, Vol.34 (15), p.1908-1918
Hauptverfasser:	Jansson, M D, Damas, N D, Lees, M, Jacobsen, A, Lund, A H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/67 631/80/86 692/699/67/581 Apoptosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Biology Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Down-Regulation Female Gene expression Genetic aspects Health aspects HEK293 Cells High-throughput screening Human Genetics Humans Internal Medicine MCF-7 Cells MDM2 protein Medicine Medicine & Public Health MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Oncology original-article p53 Protein Proteins Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Senescence Transfection Tumor cells Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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