Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time

One of the leading neurobiological hypotheses on depression states that decreased expression of brain-derived neurotrophic factor (BDNF) contributes to depression. This is supported by consistent findings of low serum BDNF levels in depressed patients compared with non-depressed controls. Whereas it...

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Veröffentlicht in:	Molecular psychiatry 2015-05, Vol.20 (5), p.602-608
Hauptverfasser:	Bus, B A A, Molendijk, M L, Tendolkar, I, Penninx, B W J H, Prickaerts, J, Elzinga, B M, Voshaar, R C O
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1686 692/699/476/1414 Adult Analysis Antidepressants Antidepressants, Tricyclic Antidepressive Agents - therapeutic use Anxiety Behavioral Sciences Biological Psychology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Care and treatment Child Child Abuse - psychology Chronic Disease Cohort analysis Comparative analysis Depression - blood Depression - classification Depression - drug therapy Depression, Mental Diagnosis Female Humans Hypotheses Longitudinal Studies Male Medicine Medicine & Public Health Mental depression Mental health Middle Aged Neurobiology Neuropsychology Neurosciences original-article Pharmacotherapy Psychiatric Status Rating Scales Psychiatry Retrospective Studies Statistics, Nonparametric Stress Stress response
Online-Zugang:	Volltext
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