The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response

Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. Transcripts of most cytokines contain adenylate‐uri...

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Veröffentlicht in:	European journal of immunology 2015-05, Vol.45 (5), p.1500-1511
Hauptverfasser:	Herdy, Barbara, Karonitsch, Thomas, Vladimer, Gregory I., Tan, Chris S.H., Stukalov, Alexey, Trefzer, Claudia, Bigenzahn, Johannes W., Theil, Tamara, Holinka, Johannes, Kiener, Hans P., Colinge, Jacques, Bennett, Keiryn L, Superti‐Furga, Giulio
Format:	Artikel
Sprache:	eng
Schlagworte:	A/U‐rich elements (AREs) Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology AU Rich Elements Base Sequence Cytokines ELAV Proteins - antagonists & inhibitors ELAV Proteins - genetics ELAV Proteins - immunology ELAV-Like Protein 1 HeLa Cells Humans HuR/ELAVL1 Immune modulation Interferon Inducers - pharmacology Interferon Type I - biosynthesis Interferon-beta - genetics Molecular Sequence Data Poly I-C - pharmacology Protein Multimerization RNA Processing, Post-Transcriptional - drug effects RNA Stability - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA‐binding proteins Synovial Membrane - immunology Type I interferon
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