The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells

Insulin-like 3 (INSL3), a hormone produced by Leydig cells, regulates testicular descent during foetal life and bone metabolism in adults. Despite its importance, little is known about the molecular mechanisms controlling INSL3 expression. Reduced Insl3 mRNA levels were reported in the testis of mic...

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Veröffentlicht in:	Journal of molecular endocrinology 2014-08, Vol.53 (1), p.43-55
Hauptverfasser:	Mendoza-Villarroel, Raifish E, Di-Luoffo, Mickaël, Camiré, Etienne, Giner, Xavier C, Brousseau, Catherine, Tremblay, Jacques J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line COUP Transcription Factor II - antagonists & inhibitors COUP Transcription Factor II - genetics COUP Transcription Factor II - metabolism Gene Expression Regulation Gene Knockdown Techniques Insulin - genetics Leydig Cells - metabolism Male Mice Promoter Regions, Genetic Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Sequence Deletion Steroidogenic Factor 1 - metabolism
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