Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)
Background Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA). Objective and hypothesis The objective of this study is to perform a longitud...
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| Veröffentlicht in: | Lupus 2014-11, Vol.23 (13), p.1392-1406 |
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| creator | Stagi, S Cavalli, L Bertini, F Signorini, C Matucci Cerinic, M de Martino, M Brandi, M L Falcini, F |
| description | Background
Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA).
Objective and hypothesis
The objective of this study is to perform a longitudinal evaluation of the prevalence and the characteristics of bone mass and quality and to evaluate the differences on the bone parameters, using DXA, pQCT and QUS.
Population and/or methods
Forty-three JSLE patients (35 females, 8 males, median age 18.8, range 14.0–34.1 years) have been studied with DXA, pQCT and QUS scans and compared with 138 JIA patients (112 females, 26 males, median age 18.9, range 13.4–33.2 years), and 79 controls (59 females, 20 males; median age 19.3, range 13.5–36.5 years). Of these, 39 patients (32 females and 7 males, median age 20.3, range 16.6–36.8 years) with JSLE were followed longitudinally and compared with 131 patients (108 females, 23 males median age 20.7, range 15.8–37.1 years) with JIA and 63 controls (48 females, 15 males; median age 21.9, range 15.5–38.3 years).
Results
JSLE patients have a higher bone cortical density (CrtBMD) than controls and JIA patients (p |
| doi_str_mv | 10.1177/0961203314543916 |
| format | Article |
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Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA).
Objective and hypothesis
The objective of this study is to perform a longitudinal evaluation of the prevalence and the characteristics of bone mass and quality and to evaluate the differences on the bone parameters, using DXA, pQCT and QUS.
Population and/or methods
Forty-three JSLE patients (35 females, 8 males, median age 18.8, range 14.0–34.1 years) have been studied with DXA, pQCT and QUS scans and compared with 138 JIA patients (112 females, 26 males, median age 18.9, range 13.4–33.2 years), and 79 controls (59 females, 20 males; median age 19.3, range 13.5–36.5 years). Of these, 39 patients (32 females and 7 males, median age 20.3, range 16.6–36.8 years) with JSLE were followed longitudinally and compared with 131 patients (108 females, 23 males median age 20.7, range 15.8–37.1 years) with JIA and 63 controls (48 females, 15 males; median age 21.9, range 15.5–38.3 years).
Results
JSLE patients have a higher bone cortical density (CrtBMD) than controls and JIA patients (p < 0.005). However, JSLE and JIA patients have a significantly reduced bone trabecular density (TrbBMD) compared to controls (p < 0.0001), with no differences between JSLE and JIA. In addition, JIA patients show a significantly reduced muscle area (MuscleCSA) compared to JSLE and controls (p < 0.001). Conversely, fat area (FatCSA) is significantly increased both in JIA and JSLE patients when compared to controls (p < 0.001), with no differences between the JSLE and JIA groups. Analogous results are observed in the polar resistance to stress (SSIp).
On longitudinal evaluation, contrary to CrtBMD, the difference between BMAD SDS, TrbBMD, MuscleCSA and FatCSA remains unchanged; in JSLE patients, SSIp is stable in comparison to JIA and controls without any difference between the two groups.
Conclusions
The evaluation of bone density and structure parameters in JSLE patients highlights significant differences compared with JIA patients and controls. These data might indicate a different pathogenesis of bone damage in the two entities, and suggest a different diagnostic and therapeutic approach to improve the peak bone mass.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203314543916</identifier><identifier>PMID: 25074873</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - diagnostic imaging ; Adolescent ; Adult ; Age ; Arthritis ; Arthritis, Juvenile - physiopathology ; Bone and Bones - diagnostic imaging ; Bone Density ; Female ; Hospitals ; Humans ; Longitudinal Studies ; Lupus ; Lupus Erythematosus, Systemic - physiopathology ; Male ; Muscle, Skeletal - diagnostic imaging ; Osteoporosis ; Rheumatology ; Teenagers ; Ultrasonography ; Young Adult ; Young adults</subject><ispartof>Lupus, 2014-11, Vol.23 (13), p.1392-1406</ispartof><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.</rights><rights>SAGE Publications © Nov 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-90af1fd73b2bdbc92127f134b1ba8ff23d6ebebcb51ec00d050972eda5aa6a5c3</citedby><cites>FETCH-LOGICAL-c440t-90af1fd73b2bdbc92127f134b1ba8ff23d6ebebcb51ec00d050972eda5aa6a5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203314543916$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203314543916$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25074873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stagi, S</creatorcontrib><creatorcontrib>Cavalli, L</creatorcontrib><creatorcontrib>Bertini, F</creatorcontrib><creatorcontrib>Signorini, C</creatorcontrib><creatorcontrib>Matucci Cerinic, M</creatorcontrib><creatorcontrib>de Martino, M</creatorcontrib><creatorcontrib>Brandi, M L</creatorcontrib><creatorcontrib>Falcini, F</creatorcontrib><title>Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Background
Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA).
Objective and hypothesis
The objective of this study is to perform a longitudinal evaluation of the prevalence and the characteristics of bone mass and quality and to evaluate the differences on the bone parameters, using DXA, pQCT and QUS.
Population and/or methods
Forty-three JSLE patients (35 females, 8 males, median age 18.8, range 14.0–34.1 years) have been studied with DXA, pQCT and QUS scans and compared with 138 JIA patients (112 females, 26 males, median age 18.9, range 13.4–33.2 years), and 79 controls (59 females, 20 males; median age 19.3, range 13.5–36.5 years). Of these, 39 patients (32 females and 7 males, median age 20.3, range 16.6–36.8 years) with JSLE were followed longitudinally and compared with 131 patients (108 females, 23 males median age 20.7, range 15.8–37.1 years) with JIA and 63 controls (48 females, 15 males; median age 21.9, range 15.5–38.3 years).
Results
JSLE patients have a higher bone cortical density (CrtBMD) than controls and JIA patients (p < 0.005). However, JSLE and JIA patients have a significantly reduced bone trabecular density (TrbBMD) compared to controls (p < 0.0001), with no differences between JSLE and JIA. In addition, JIA patients show a significantly reduced muscle area (MuscleCSA) compared to JSLE and controls (p < 0.001). Conversely, fat area (FatCSA) is significantly increased both in JIA and JSLE patients when compared to controls (p < 0.001), with no differences between the JSLE and JIA groups. Analogous results are observed in the polar resistance to stress (SSIp).
On longitudinal evaluation, contrary to CrtBMD, the difference between BMAD SDS, TrbBMD, MuscleCSA and FatCSA remains unchanged; in JSLE patients, SSIp is stable in comparison to JIA and controls without any difference between the two groups.
Conclusions
The evaluation of bone density and structure parameters in JSLE patients highlights significant differences compared with JIA patients and controls. These data might indicate a different pathogenesis of bone damage in the two entities, and suggest a different diagnostic and therapeutic approach to improve the peak bone mass.</description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - physiopathology</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone Density</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Male</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Osteoporosis</subject><subject>Rheumatology</subject><subject>Teenagers</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtr3DAUhUVpaSZp910VQTfJwq1etsfLMKR5MNBF27WRrOuMBlty9EjxX-qvrJxJQgkUuhL33O8ccTkIfaDkM6V1_YU0FWWEcypKwRtavUIrKuq6yDp7jVbLulj2R-g4hD0hhNOmeouOWElqsa75Cv3euHGS3gRnseuxchbwKEPA0mp8l-Rg4ow1RPCjsdLGgI3FUrsBQgfLuHCzS_Y2q2nIwi8Td3if7sGaAXCYQ4TRdHhIUwoY_Bx3MMroQp5Ob75vL84eIp4NRhs3ybjLFunjzptoFvD6_OwdetPLIcD7x_cE_fx68WNzVWy_XV5vzrdFJwSJRUNkT3tdc8WUVl3DKKt7yoWiSq77nnFdgQLVqZJCR4gmJWlqBlqWUlay7PgJOj3kTt7dJQixHU0-dhikBZdCS6s15yXhovwPlPJGcEZFRj-9QPcueZsPWShR5cZKlilyoDrvQvDQt5M3o_RzS0m7VN6-rDxbPj4GJzWCfjY8dZyB4gAEeQt__fqvwD9er7ZB</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Stagi, S</creator><creator>Cavalli, L</creator><creator>Bertini, F</creator><creator>Signorini, C</creator><creator>Matucci Cerinic, M</creator><creator>de Martino, M</creator><creator>Brandi, M L</creator><creator>Falcini, F</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20141101</creationdate><title>Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)</title><author>Stagi, S ; Cavalli, L ; Bertini, F ; Signorini, C ; Matucci Cerinic, M ; de Martino, M ; Brandi, M L ; Falcini, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-90af1fd73b2bdbc92127f134b1ba8ff23d6ebebcb51ec00d050972eda5aa6a5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - physiopathology</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone Density</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Male</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Osteoporosis</topic><topic>Rheumatology</topic><topic>Teenagers</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stagi, S</creatorcontrib><creatorcontrib>Cavalli, L</creatorcontrib><creatorcontrib>Bertini, F</creatorcontrib><creatorcontrib>Signorini, C</creatorcontrib><creatorcontrib>Matucci Cerinic, M</creatorcontrib><creatorcontrib>de Martino, M</creatorcontrib><creatorcontrib>Brandi, M L</creatorcontrib><creatorcontrib>Falcini, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stagi, S</au><au>Cavalli, L</au><au>Bertini, F</au><au>Signorini, C</au><au>Matucci Cerinic, M</au><au>de Martino, M</au><au>Brandi, M L</au><au>Falcini, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>23</volume><issue>13</issue><spage>1392</spage><epage>1406</epage><pages>1392-1406</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Background
Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA).
Objective and hypothesis
The objective of this study is to perform a longitudinal evaluation of the prevalence and the characteristics of bone mass and quality and to evaluate the differences on the bone parameters, using DXA, pQCT and QUS.
Population and/or methods
Forty-three JSLE patients (35 females, 8 males, median age 18.8, range 14.0–34.1 years) have been studied with DXA, pQCT and QUS scans and compared with 138 JIA patients (112 females, 26 males, median age 18.9, range 13.4–33.2 years), and 79 controls (59 females, 20 males; median age 19.3, range 13.5–36.5 years). Of these, 39 patients (32 females and 7 males, median age 20.3, range 16.6–36.8 years) with JSLE were followed longitudinally and compared with 131 patients (108 females, 23 males median age 20.7, range 15.8–37.1 years) with JIA and 63 controls (48 females, 15 males; median age 21.9, range 15.5–38.3 years).
Results
JSLE patients have a higher bone cortical density (CrtBMD) than controls and JIA patients (p < 0.005). However, JSLE and JIA patients have a significantly reduced bone trabecular density (TrbBMD) compared to controls (p < 0.0001), with no differences between JSLE and JIA. In addition, JIA patients show a significantly reduced muscle area (MuscleCSA) compared to JSLE and controls (p < 0.001). Conversely, fat area (FatCSA) is significantly increased both in JIA and JSLE patients when compared to controls (p < 0.001), with no differences between the JSLE and JIA groups. Analogous results are observed in the polar resistance to stress (SSIp).
On longitudinal evaluation, contrary to CrtBMD, the difference between BMAD SDS, TrbBMD, MuscleCSA and FatCSA remains unchanged; in JSLE patients, SSIp is stable in comparison to JIA and controls without any difference between the two groups.
Conclusions
The evaluation of bone density and structure parameters in JSLE patients highlights significant differences compared with JIA patients and controls. These data might indicate a different pathogenesis of bone damage in the two entities, and suggest a different diagnostic and therapeutic approach to improve the peak bone mass.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25074873</pmid><doi>10.1177/0961203314543916</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2014-11, Vol.23 (13), p.1392-1406 |
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| language | eng |
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| subjects | Absorptiometry, Photon Adipose Tissue - diagnostic imaging Adolescent Adult Age Arthritis Arthritis, Juvenile - physiopathology Bone and Bones - diagnostic imaging Bone Density Female Hospitals Humans Longitudinal Studies Lupus Lupus Erythematosus, Systemic - physiopathology Male Muscle, Skeletal - diagnostic imaging Osteoporosis Rheumatology Teenagers Ultrasonography Young Adult Young adults |
| title | Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA) |
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