Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain
The structure and function of the arcuate fascicle is still controversial. The goal of this study was to investigate the asymmetry, connectivity, and segmentation patterns of the arcuate fascicle. We employed diffusion spectrum imaging reconstructed by generalized q-sampling and we applied both a su...
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description | The structure and function of the arcuate fascicle is still controversial. The goal of this study was to investigate the asymmetry, connectivity, and segmentation patterns of the arcuate fascicle. We employed diffusion spectrum imaging reconstructed by generalized q-sampling and we applied both a subject-specific approach (10 subjects) and a template approach (q-space diffeomorphic reconstruction of 30 subjects). We complemented our imaging investigation with fiber microdissection of five post-mortem human brains. Our results confirmed the highly leftward asymmetry of the arcuate fascicle. In the template, the left arcuate had a volume twice as large as the right one, and the left superior temporal gyrus provided five times more volume of fibers than its counterpart. We identified four cortical frontal areas of termination: pars opercularis, pars triangularis, ventral precentral gyrus, and caudal middle frontal gyrus. We found clear asymmetry of the frontal terminations at pars opercularis and ventral precentral gyrus. The analysis of patterns of connectivity revealed the existence of a strong structural segmentation in the left arcuate, but not in the right one. The left arcuate fascicle is formed by an
inner or ventral pathway
, which interconnects pars opercularis with superior and rostral middle temporal gyri; and an
outer or dorsal pathway
, which interconnects ventral precentral and caudal middle frontal gyri with caudal middle and inferior temporal gyri. The fiber microdissection results provided further support to our tractography studies. We propose the existence of
primary and supplementary language pathways
within the dominant arcuate fascicle with potentially distinct functional and lesional features. |
doi_str_mv | 10.1007/s00429-014-0751-7 |
format | Article |
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inner or ventral pathway
, which interconnects pars opercularis with superior and rostral middle temporal gyri; and an
outer or dorsal pathway
, which interconnects ventral precentral and caudal middle frontal gyri with caudal middle and inferior temporal gyri. The fiber microdissection results provided further support to our tractography studies. We propose the existence of
primary and supplementary language pathways
within the dominant arcuate fascicle with potentially distinct functional and lesional features.</description><identifier>ISSN: 1863-2653</identifier><identifier>EISSN: 1863-2661</identifier><identifier>EISSN: 0340-2061</identifier><identifier>DOI: 10.1007/s00429-014-0751-7</identifier><identifier>PMID: 24633827</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Frontal Lobe - anatomy & histology ; Functional Laterality ; Humans ; Language ; Male ; Neural Pathways - anatomy & histology ; Neurology ; Neurosciences ; Original Article ; Scientific imaging ; Temporal Lobe - anatomy & histology ; White Matter - anatomy & histology ; Young Adult</subject><ispartof>Brain Structure and Function, 2015-05, Vol.220 (3), p.1665-1680</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-ae0e58ce9de406d29c3134f449462344218032fb67d2c5613bafcbbbcc575d9e3</citedby><cites>FETCH-LOGICAL-c471t-ae0e58ce9de406d29c3134f449462344218032fb67d2c5613bafcbbbcc575d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00429-014-0751-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00429-014-0751-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24633827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Miranda, Juan C.</creatorcontrib><creatorcontrib>Wang, Yibao</creatorcontrib><creatorcontrib>Pathak, Sudhir</creatorcontrib><creatorcontrib>Stefaneau, Lucia</creatorcontrib><creatorcontrib>Verstynen, Timothy</creatorcontrib><creatorcontrib>Yeh, Fang-Cheng</creatorcontrib><title>Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain</title><title>Brain Structure and Function</title><addtitle>Brain Struct Funct</addtitle><addtitle>Brain Struct Funct</addtitle><description>The structure and function of the arcuate fascicle is still controversial. The goal of this study was to investigate the asymmetry, connectivity, and segmentation patterns of the arcuate fascicle. We employed diffusion spectrum imaging reconstructed by generalized q-sampling and we applied both a subject-specific approach (10 subjects) and a template approach (q-space diffeomorphic reconstruction of 30 subjects). We complemented our imaging investigation with fiber microdissection of five post-mortem human brains. Our results confirmed the highly leftward asymmetry of the arcuate fascicle. In the template, the left arcuate had a volume twice as large as the right one, and the left superior temporal gyrus provided five times more volume of fibers than its counterpart. We identified four cortical frontal areas of termination: pars opercularis, pars triangularis, ventral precentral gyrus, and caudal middle frontal gyrus. We found clear asymmetry of the frontal terminations at pars opercularis and ventral precentral gyrus. The analysis of patterns of connectivity revealed the existence of a strong structural segmentation in the left arcuate, but not in the right one. The left arcuate fascicle is formed by an
inner or ventral pathway
, which interconnects pars opercularis with superior and rostral middle temporal gyri; and an
outer or dorsal pathway
, which interconnects ventral precentral and caudal middle frontal gyri with caudal middle and inferior temporal gyri. The fiber microdissection results provided further support to our tractography studies. We propose the existence of
primary and supplementary language pathways
within the dominant arcuate fascicle with potentially distinct functional and lesional features.</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Frontal Lobe - anatomy & histology</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Language</subject><subject>Male</subject><subject>Neural Pathways - anatomy & histology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Scientific imaging</subject><subject>Temporal Lobe - anatomy & histology</subject><subject>White Matter - anatomy & histology</subject><subject>Young Adult</subject><issn>1863-2653</issn><issn>1863-2661</issn><issn>0340-2061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctKxTAQhoMo3h_AjRTcuLCaybVZysEbCG50HdJ0qpXTVJNUOG9vj0dFBMFVJplv_iF8hBwAPQVK9VmiVDBTUhAl1RJKvUa2oVK8ZErB-nct-RbZSemZUmkqMJtkiwnFecX0Nrk_T4u-xxwXJ4UfQkCfu7cuTzcXmiLhY48hu9wNoRjaIj9h4aIfXcaidcl3fo5FFz7en8behaKOrgt7ZKN184T7n-cuebi8uJ9dl7d3Vzez89vSCw25dEhRVh5Ng4KqhhnPgYtWCCMU40IwqChnba10w7xUwGvX-rquvZdaNgb5Ljle5b7E4XXElG3fJY_zuQs4jMmCqjgXRkr4B6oVFwB6iR79Qp-HMYbpI0tKSkOFEBMFK8rHIaWIrX2JXe_iwgK1Szt2ZcdOduzSjtXTzOFn8lj32HxPfOmYALYC0tQKjxh_rP4z9R14XZjg</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Fernández-Miranda, Juan C.</creator><creator>Wang, Yibao</creator><creator>Pathak, Sudhir</creator><creator>Stefaneau, Lucia</creator><creator>Verstynen, Timothy</creator><creator>Yeh, Fang-Cheng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain</title><author>Fernández-Miranda, Juan C. ; Wang, Yibao ; Pathak, Sudhir ; Stefaneau, Lucia ; Verstynen, Timothy ; Yeh, Fang-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-ae0e58ce9de406d29c3134f449462344218032fb67d2c5613bafcbbbcc575d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Frontal Lobe - anatomy & histology</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Language</topic><topic>Male</topic><topic>Neural Pathways - anatomy & histology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Scientific imaging</topic><topic>Temporal Lobe - anatomy & histology</topic><topic>White Matter - anatomy & histology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Miranda, Juan C.</creatorcontrib><creatorcontrib>Wang, Yibao</creatorcontrib><creatorcontrib>Pathak, Sudhir</creatorcontrib><creatorcontrib>Stefaneau, Lucia</creatorcontrib><creatorcontrib>Verstynen, Timothy</creatorcontrib><creatorcontrib>Yeh, Fang-Cheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain Structure and Function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Miranda, Juan C.</au><au>Wang, Yibao</au><au>Pathak, Sudhir</au><au>Stefaneau, Lucia</au><au>Verstynen, Timothy</au><au>Yeh, Fang-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain</atitle><jtitle>Brain Structure and Function</jtitle><stitle>Brain Struct Funct</stitle><addtitle>Brain Struct Funct</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>220</volume><issue>3</issue><spage>1665</spage><epage>1680</epage><pages>1665-1680</pages><issn>1863-2653</issn><eissn>1863-2661</eissn><eissn>0340-2061</eissn><abstract>The structure and function of the arcuate fascicle is still controversial. The goal of this study was to investigate the asymmetry, connectivity, and segmentation patterns of the arcuate fascicle. We employed diffusion spectrum imaging reconstructed by generalized q-sampling and we applied both a subject-specific approach (10 subjects) and a template approach (q-space diffeomorphic reconstruction of 30 subjects). We complemented our imaging investigation with fiber microdissection of five post-mortem human brains. Our results confirmed the highly leftward asymmetry of the arcuate fascicle. In the template, the left arcuate had a volume twice as large as the right one, and the left superior temporal gyrus provided five times more volume of fibers than its counterpart. We identified four cortical frontal areas of termination: pars opercularis, pars triangularis, ventral precentral gyrus, and caudal middle frontal gyrus. We found clear asymmetry of the frontal terminations at pars opercularis and ventral precentral gyrus. The analysis of patterns of connectivity revealed the existence of a strong structural segmentation in the left arcuate, but not in the right one. The left arcuate fascicle is formed by an
inner or ventral pathway
, which interconnects pars opercularis with superior and rostral middle temporal gyri; and an
outer or dorsal pathway
, which interconnects ventral precentral and caudal middle frontal gyri with caudal middle and inferior temporal gyri. The fiber microdissection results provided further support to our tractography studies. We propose the existence of
primary and supplementary language pathways
within the dominant arcuate fascicle with potentially distinct functional and lesional features.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24633827</pmid><doi>10.1007/s00429-014-0751-7</doi><tpages>16</tpages></addata></record> |
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subjects | Adult Biomedical and Life Sciences Biomedicine Brain Cell Biology Diffusion Magnetic Resonance Imaging - methods Female Frontal Lobe - anatomy & histology Functional Laterality Humans Language Male Neural Pathways - anatomy & histology Neurology Neurosciences Original Article Scientific imaging Temporal Lobe - anatomy & histology White Matter - anatomy & histology Young Adult |
title | Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain |
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