Interaction Between MAOA and FOXP2 in Association With Autism and Verbal Communication in a Korean Population
Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development a...
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| Veröffentlicht in: | Journal of child neurology 2014-12, Vol.29 (12), p.NP207-NP211 |
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| container_issue | 12 |
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| container_title | Journal of child neurology |
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| creator | Park, YoungJoon Won, SeongSik Nam, Min Chung, Joo-Ho Kwack, KyuBum |
| description | Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. For this reason, we undertook interaction analysis between MAOA and FOXP2 in autism spectrum disorder, including testing the verbal communication score of the childhood autism rating scale. In interaction analysis, the FOXP2-TCGC (rs12531289-rs1350135-rs10230087-rs2061183) diplotype and MAOA-TCG (rs6323-rs1801291-rs3027407) haplotype were significantly associated with autism spectrum disorder in males. However, when the interaction term was omitted, neither MAOA nor FOXP2 was associated with autism spectrum disorder or verbal communication. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately. |
| doi_str_mv | 10.1177/0883073813511301 |
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Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. For this reason, we undertook interaction analysis between MAOA and FOXP2 in autism spectrum disorder, including testing the verbal communication score of the childhood autism rating scale. In interaction analysis, the FOXP2-TCGC (rs12531289-rs1350135-rs10230087-rs2061183) diplotype and MAOA-TCG (rs6323-rs1801291-rs3027407) haplotype were significantly associated with autism spectrum disorder in males. However, when the interaction term was omitted, neither MAOA nor FOXP2 was associated with autism spectrum disorder or verbal communication. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/0883073813511301</identifier><identifier>PMID: 24356376</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Autistic Disorder - epidemiology ; Autistic Disorder - genetics ; Child ; Communicable Diseases - epidemiology ; Communicable Diseases - genetics ; Female ; Forkhead Transcription Factors - genetics ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Monoamine Oxidase - genetics ; Polymorphism, Single Nucleotide - genetics ; Republic of Korea - epidemiology ; Verbal Behavior - physiology ; Young Adult</subject><ispartof>Journal of child neurology, 2014-12, Vol.29 (12), p.NP207-NP211</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-4df4121bb711238078d798650d28fe93f4b9d517a02c9f95cf9b0aecc66a0a433</citedby><cites>FETCH-LOGICAL-c370t-4df4121bb711238078d798650d28fe93f4b9d517a02c9f95cf9b0aecc66a0a433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0883073813511301$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0883073813511301$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21823,27928,27929,43625,43626</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24356376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, YoungJoon</creatorcontrib><creatorcontrib>Won, SeongSik</creatorcontrib><creatorcontrib>Nam, Min</creatorcontrib><creatorcontrib>Chung, Joo-Ho</creatorcontrib><creatorcontrib>Kwack, KyuBum</creatorcontrib><title>Interaction Between MAOA and FOXP2 in Association With Autism and Verbal Communication in a Korean Population</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. For this reason, we undertook interaction analysis between MAOA and FOXP2 in autism spectrum disorder, including testing the verbal communication score of the childhood autism rating scale. In interaction analysis, the FOXP2-TCGC (rs12531289-rs1350135-rs10230087-rs2061183) diplotype and MAOA-TCG (rs6323-rs1801291-rs3027407) haplotype were significantly associated with autism spectrum disorder in males. However, when the interaction term was omitted, neither MAOA nor FOXP2 was associated with autism spectrum disorder or verbal communication. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately.</description><subject>Adolescent</subject><subject>Autistic Disorder - epidemiology</subject><subject>Autistic Disorder - genetics</subject><subject>Child</subject><subject>Communicable Diseases - epidemiology</subject><subject>Communicable Diseases - genetics</subject><subject>Female</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Monoamine Oxidase - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Republic of Korea - epidemiology</subject><subject>Verbal Behavior - physiology</subject><subject>Young Adult</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1PwzAUxC0EoqWwMyGPLIHn2ImdMVQUKoraga8tchwHUiV2sRMh_nvSDxiQENOT3v3uhjuETglcEML5JQhBgVNBaEQIBbKHhoSDCEQo6D4aruVgrQ_QkfdLABBRAodoEDIaxZTHQ9RMTaudVG1lDb7S7YfWBt-n8xRLU-DJ_GUR4srg1HurKrmhnqv2DaddW_lmAz1pl8saj23TdKZSW6j3SHxnnZYGL-yqqzfvY3RQytrrk90docfJ9cP4NpjNb6bjdBYoyqENWFEyEpI854SEVAAXBU9EHEERilIntGR5UkSESwhVUiaRKpMcpFYqjiVIRukInW9zV86-d9q3WVN5petaGm07n5FYUMoE67v5Hw1ZQiPO4h6FLaqc9d7pMlu5qpHuMyOQrffIfu_RW8526V3e6OLH8D1ADwRbwMtXnS1t50xfzN-BX8J9kJY</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Park, YoungJoon</creator><creator>Won, SeongSik</creator><creator>Nam, Min</creator><creator>Chung, Joo-Ho</creator><creator>Kwack, KyuBum</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201412</creationdate><title>Interaction Between MAOA and FOXP2 in Association With Autism and Verbal Communication in a Korean Population</title><author>Park, YoungJoon ; Won, SeongSik ; Nam, Min ; Chung, Joo-Ho ; Kwack, KyuBum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4df4121bb711238078d798650d28fe93f4b9d517a02c9f95cf9b0aecc66a0a433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Autistic Disorder - epidemiology</topic><topic>Autistic Disorder - genetics</topic><topic>Child</topic><topic>Communicable Diseases - epidemiology</topic><topic>Communicable Diseases - genetics</topic><topic>Female</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Monoamine Oxidase - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Republic of Korea - epidemiology</topic><topic>Verbal Behavior - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, YoungJoon</creatorcontrib><creatorcontrib>Won, SeongSik</creatorcontrib><creatorcontrib>Nam, Min</creatorcontrib><creatorcontrib>Chung, Joo-Ho</creatorcontrib><creatorcontrib>Kwack, KyuBum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, YoungJoon</au><au>Won, SeongSik</au><au>Nam, Min</au><au>Chung, Joo-Ho</au><au>Kwack, KyuBum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction Between MAOA and FOXP2 in Association With Autism and Verbal Communication in a Korean Population</atitle><jtitle>Journal of child neurology</jtitle><addtitle>J Child Neurol</addtitle><date>2014-12</date><risdate>2014</risdate><volume>29</volume><issue>12</issue><spage>NP207</spage><epage>NP211</epage><pages>NP207-NP211</pages><issn>0883-0738</issn><eissn>1708-8283</eissn><abstract>Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. For this reason, we undertook interaction analysis between MAOA and FOXP2 in autism spectrum disorder, including testing the verbal communication score of the childhood autism rating scale. In interaction analysis, the FOXP2-TCGC (rs12531289-rs1350135-rs10230087-rs2061183) diplotype and MAOA-TCG (rs6323-rs1801291-rs3027407) haplotype were significantly associated with autism spectrum disorder in males. However, when the interaction term was omitted, neither MAOA nor FOXP2 was associated with autism spectrum disorder or verbal communication. These results indicate that language and speech ability is affected by an interaction between FOXP2 and MAOA, but not by either gene separately.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>24356376</pmid><doi>10.1177/0883073813511301</doi></addata></record> |
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| subjects | Adolescent Autistic Disorder - epidemiology Autistic Disorder - genetics Child Communicable Diseases - epidemiology Communicable Diseases - genetics Female Forkhead Transcription Factors - genetics Gene Frequency Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype Humans Linkage Disequilibrium Male Monoamine Oxidase - genetics Polymorphism, Single Nucleotide - genetics Republic of Korea - epidemiology Verbal Behavior - physiology Young Adult |
| title | Interaction Between MAOA and FOXP2 in Association With Autism and Verbal Communication in a Korean Population |
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